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    • Study on the dynamic balance ability of young adults under different obstacle-crossing strategies
    XU Haoran , WANG Ruiqin , CAO Jinfeng , ZHANG Linlin , Han Jia
    Adopted date: March 17,2025
    [Abstract](2) [HTML](0) [PDF 0.00 Byte](0)
    Abstract:
    Objective This study aims to investigate the dynamic balance ability of healthy young adults under different obstacle-crossing strategies. Methods Twenty healthy young adults used F-scan plantar pressure analysis insoles for the experiment. In this study, participants were asked to cross three obstacles with different combinations of height and width (Obstacle 1: 30cm*25cm, Obstacle 2: 15cm*25cm, Obstacle 3: 15cm*50cm), using their dominant foot as the leading foot and the non-dominant foot as the trailing foot. They were instructed to perform both lateral and forward crossing methods, during which plantar pressure data were collected. Results The results revealed that different crossing strategies significantly affected the adjustment speed of the leading foot"s Center of Pressure (COP)_ML, the area of the 95% confidence circle, ML amplitude, and AP amplitude, with the differences being statistically significant (p<0.05). The crossing strategies also had a significant impact on the trailing foot"s COP_ML adjustment speed, the area of the 95% confidence circle, and the differences between maximum and minimum swing, with these differences being statistically significant. For the leading foot, during lateral and forward crossing, the balance parameter values under different heights and widths were statistically significant, with the balance parameter values increasing as height increased and as width expanded. For the trailing foot, during forward crossing, the balance parameter values under different heights were statistically significant, with the values increasing as height increased, whereas during lateral crossing, the differences were not significant. Conclusions This study found that healthy young adults have better balance ability with the leading foot when crossing obstacles longitudinally, which is consistent with the dominant foot’s movement habits and daily activity patterns. Conversely, the following foot exhibits a more stable plantar pressure distribution when crossing laterally, which may be related to a larger contact area and more even distribution of the center of gravity.
    Antibacterial Effect of Barium Copper Titanate Piezoelectric Material Coupled with Ultrasound In Vitro
    Yi Wang , Yunshun Tao , Biaohong Huang , Weijin Hu , Shujun Li , Qiang Wu , Yilai Jiao
    Adopted date: March 17,2025
    [Abstract](1) [HTML](0) [PDF 0.00 Byte](0)
    Abstract:
    Objective: To investigate the therapeutic effects of copper-doped barium titanate (BaTiO?) piezoelectric materials combined with low-intensity pulsed ultrasound (LIPUS) in activating their piezoelectric-catalytic synergistic effect for the treatment of implant-associated infections. Methods: Copper-doped barium titanate coatings were synthesized on the surface of Ti-6Al-4V substrates using a hydrothermal method, and their surface morphology was characterized by scanning electron microscopy (SEM). The piezoelectric characteristics of the coatings were analyzed using piezoresponse force microscopy (PFM). An in vitro biofilm model of methicillin-resistant Staphylococcus aureus (MRSA) was used, with barium titanate coatings serving as the control group. With LIPUS intervention (1.0 W/cm2, 1 MHz, 10 minutes), bacterial viability was assessed using colony counting to evaluate the antibacterial performance of the copper-doped barium titanate coatings. Confocal microscopy was used to observe biofilm viability in different groups, assessing the biofilm removal capability of the coatings. Reactive oxygen species (ROS) generation in each group was detected using Rhodamine b as a probe to evaluate the catalytic efficiency of the coatings in generating ROS. Results: Copper doping effectively reduced the piezoelectric coefficient (d??) of the coatings from 17.7 pm/V to 7.8 pm/V, making their piezoelectric properties more compatible with those of natural bone tissue. Under LIPUS intervention, the copper-doped barium titanate coatings exhibited significantly enhanced ROS generation and antibacterial performance, achieving a bacterial killing rate of over 90% while effectively removing MRSA biofilms. Confocal microscopy revealed that the coatings almost completely disintegrated bacterial biofilms under ultrasound, with a marked reduction in bacterial viability. Conclusion: The copper-doped barium titanate coatings achieved efficient antibacterial and biofilm-clearing functions through a piezoelectric-catalytic synergistic mechanism. Their piezoelectric properties are well-matched with those of natural bone tissue, supporting implant osseointegration.
    Experimental Study of Manual Acupuncture on Analgesic Effects via Mast Cell Degranulation in AA Rat Models
    ZHANG ZI LIANG , YU YI , QIAO XUAN , CHEN EN NA , XU JING WEN , YAO WEI
    Adopted date: March 14,2025
    [Abstract](5) [HTML](0) [PDF 0.00 Byte](0)
    Abstract:
    Objective To evaluate the analgesic effect of manual acupuncture on acute adjuvant arthritis (AA) rats, using flurbiprofen cataplasm as a positive control, and its correlation with mast cell degranulation. Methods 24 SD rats were randomly divided into three groups: model group, 10-minute manual acupuncture group, and 30-minute flurbiprofen cataplasm treatment group. AArat models were employed, and treatments were applied at the Zusanli acupoint. The rats’ pain thresholds under mechanical and thermal stimuli were measured before and after the therapy, and the analgesic effects were evaluated using the pain threshold recovery rate (PTRR). The mast cell degranulation rate at the acupoint tissue was calculated, and a correlation analysis was performed between the PTRR and mast cell degranulation rate. Results Mechanical and thermal pain thresholds were significantly increased in 10-minute manual acupuncture group compared to before therapy (P?＜?0.0001), while the PTRR results were similar to 30-minute flurbiprofen cataplasm treatment group (P?＞?0.05). The mast cell degranulation rate in the 10-minute manual acupuncture group and the 30-minute flurbiprofen cataplasm treatment group was significantly higher than the model group (P＜0.001). Conclusions Short-term application of manual acupuncture provides immediate analgesia in AA rats, comparable to flurbiprofen cataplasm treatment. The analgesic effects of manual acupuncture and flurbiprofen cataplasm treatment may be closely related to the degranulation of mast cells in the Zusanli acupoint tissue. This study provides an optimized clinical protocol for treating inflammatory joint diseases while laying the groundwork for future research on treatment mechanisms, long-term outcomes, and combination therapy applicability in varied patient groups.
    Net Meta-analysis of the Effects of Different Exercise Modalities on Working Memory in Children with Attention Deficit Hyperactivity Disorder (ADHD)
    liudongfei , libaoguo
    Adopted date: March 14,2025
    [Abstract](6) [HTML](0) [PDF 0.00 Byte](0)
    Abstract:
    As an activity from early childhood to adulthood, sports have a continuous positive impact on individual cognitive function, which not only reflects the health benefits of sports in many aspects, but also provides a solid physiological basis for exercise intervention in ADHD. Although a number of studies have addressed the relationship between physical activity and working memory in ADHD children, the actual effect of exercise intervention is still controversial. This phenomenon may be due to the fact that most of the existing studies analyze working memory as a whole, without further exploring the intervention effect of its specific dimensions. In addition, the type of exercise may be a key factor affecting the change of working memory, but there is no systematic comparison of the effects of different exercise modes on the working memory of ADHD children. In view of this, this study first used the traditional meta-analysis method to quantitatively integrate and comprehensively analyze the relationship between exercise and ADHD children 's working memory and its different dimensions. Secondly, the network meta-analysis method was used to compare the relative intervention effects of different exercise modes on visual working memory and verbal working memory of ADHD children. In order to provide theoretical basis and practical guidance for the optimization and scientific selection of intervention programs for children with ADHD.
    Bioprinting Fabrication and Biomechanical Functional Evaluation of Microvascular Networks
    Yubo Fan
    Adopted date: March 11,2025
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    Abstract:
    Constructing functional microvascular networks in vitro represents a pivotal step in the creation of engineered tissues, organ-on-chip models, and organoids, holding profound implications for tissue engineering, regenerative medicine, drug screening, and disease modeling. As a cutting-edge bio-manufacturing approach, bioprinting enables the precise deposition of biomaterials, cells, and bioactive molecules to fabricate intricate microvascular networks that faithfully replicate the geometric architecture and functional properties of native microvasculature. This review summarizes the research progress in bioprinting microvascular networks, with a focus on bioprinting technologies, bioinks, and the biomechanical functional evaluation of microvascular networks. This review provides an overview recent advances in bioprinting microvascular networks, highlighting key developments in bioprinting technologies, bioinks and the biomechanical functional evaluation of microvascular networks.
    Biomechanical Analysis of the Buffering Effect of Cerebrospinal Fluid on the Spinal Cord in Patients with Scoliosis
    LIFENG , FURONGCHANG , CHENYONGHAO , ZHOUJIALIANG
    Adopted date: March 11,2025
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    Abstract:
    To investigate the protective effect of cerebrospinal fluid (CSF) on the spinal cord in patients with scoliosis and evaluate its buffering effect during gravitational traction surgery and in daily life. This study aims to provide theoretical guidance for surgical planning and postoperative rehabilitation of scoliosis.Methods: A three-dimensional coupled spinal cord-CSF finite element model was established to simulate the biomechanical responses of the spine under two scenarios: gravitational traction surgery and daily life. Comparative analyses were conducted for scenarios with and without CSF, and the buffering effect of CSF was quantitatively assessed.Results: During gravitational traction surgery, CSF significantly reduced the stress and deformation of the spinal cord, with the stress in spinal cord white and gray matter decreasing by 65%-90% and deformation decreasing by 70%-95%. In the daily life scenario, CSF provided greater protective effects in lateral flexion and forward-backward flexion directions, with stress reductions of 60%-85%. However, in torsion, the buffering effect of CSF was relatively weaker, with stress reductions of only 10%-25%.Conclusion: CSF significantly reduces spinal cord stress and deformation during gravitational traction surgery and in daily life, lowering the risk of injury. This study provides a reference for the development of future spinal biomechanics models and offers important biomechanical evidence for the surgical planning and rehabilitation training of scoliosis. It also highlights the importance of maintaining CSF integrity during surgery.
    Dynamic Analysis of Virus Immune System with Time Delay
    Li Yangjuan
    Adopted date: March 11,2025
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    Objective This paper studied the dynamical characteristics of a virus immune infection models under the influence of immune intensity and time delay. Methods First, we determined the critical value of immune intensity through theoretical derivation and used numerical simulations to verify that the virus immune system underwent saddle node bifurcation at this critical point. Second, we constructed a virus immune model with time delay, solved the equilibrium points using linear stability analysis, and determined the stability of these equilibrium points based on the sign of the real part of the characteristic roots. Finally, we studied the impact of time delay on dynamics. Results The equilibrium points of the system with delay include saddle, stable node, stable focus, and unstable node. It implied that system exhibited bistable phenomena. The stable focus became unstable as the delay increased, leading to Hopf bifurcations. The system transitioned from a stable convergent equilibrium to a periodic oscillatory state, ultimately resulting in a viral outbreak. The stability of unstable node is unaffected by time delay, but the system"s final convergence may have changed with increasing time delay. Conclusions The results of the study are helpful to further understand dynamic mechanisms of virus immune infection system, and provide a theoretical basis for formulating reasonable and effective treatment strategies.
    The effect of different approaches of intramedullary nail fixation on postoperative biomechanical stability and early weight-bearing in patients with tibial fractures
    Zhang Dawei , Chen Ming , Han Qi
    Adopted date: March 10,2025
    [Abstract](5) [HTML](0) [PDF 0.00 Byte](0)
    Abstract:
    Objective To explore the effect of different approaches of intramedullary nail fixation on postoperative biomechanical stability and early weight-bearing in patients with tibial fractures. Methods A retrospective analysis was conducted on the medical records of 86 patients with tibial fractures admitted to the hospital from June 2018 to March 2024. The control group received intramedullary nail fixation through the infrapatellar approach, while the observation group received intramedullary nail fixation through the suprapatellar approach. Compare the intraoperative conditions, postoperative healing, knee joint stability and range of motion, hemorheology, and postoperative complications between two groups. Compare the recovery of knee joint function among patients in different weight-bearing groups, with early weight-bearing recorded within 4 weeks after surgery and late weight-bearing recorded 4 weeks after surgery. Results The observation group had fewer intraoperative fluoroscopy sessions than the control group (P<0.05). The normal healing rate of fractures in the observation group was higher than that in the control group (P<0.05). Three months after surgery, the Lysholm score, HSS score, and flexion range of motion in the observation group were higher than those in the control group (P<0.05). Six months after surgery, both groups showed an increase in Lysholm score, HSS score, and flexion range of motion (P<0.05), with the observation group having higher Lysholm score and HSS score than the control group (P<0.05). After surgery, plasma viscosity, hematocrit, and erythrocyte sedimentation rate decreased in both groups (P<0.05), with the observation group being lower than the control group (P<0.05). Among 86 patients with tibial fractures, 52 had early weight-bearing and 34 had late weight-bearing. At 3 and 6 months after surgery, the Lysholm score, HSS score, and flexion range of motion of early negative recombination were higher than those of late negative recombination (P<0.05). Conclusion The treatment of tibial fractures with intramedullary nail fixation through the anterior patellar approach can help promote the recovery of lower limb motor function in patients after surgery, and early postoperative weight-bearing can help promote the recovery of knee joint function.
    Impact of Traction Site and Direction on Maxillary and Upper Dentition in Clear Aligners Combined with Maxillary Protraction
    Zhang Qianwen , Jiang Chunmiao , Liu Yi , Ma Xiangyu , Shang Tianwei , Yang Zhijie , Fan Cunhui
    Adopted date: March 10,2025
    [Abstract](8) [HTML](0) [PDF 0.00 Byte](0)
    Abstract:
    Objective Through a three-dimensional finite element method study, this research analyzes the effects of different traction sites and directions on the maxilla and upper dentition when using clear aligners combined with protraction, aiming to guide clinicians in scientifically selecting traction sites and directions when applying clear aligners combined with protraction for the treatment of skeletal Class III malocclusion. Methods Finite element models of the zygomaticomaxillary complex, maxillary dentition, and clear aligners were constructed. The models were divided into Group G1 (traction hook at the distal of lateral incisor) and Group G2 (traction hook at the distal of canine). Each group was analyzed under four loading conditions with protraction angles of 0°, 10°, 20°, and 30° relative to the occlusal plane. A unilateral protraction force of 500g was applied. The stress distribution and displacement of maxillary bone and dentition were analyzed. Results 1. When the protraction angle was 30°, both groups showed forward and downward displacement of the maxilla, while other angles resulted in counterclockwise rotation. Under the same protraction direction, Group G2 showed greater displacement than Group G1(total displacement: G1-30° : 0.0073mm; G2-30：0.0093mm). 2. The upper central incisors in Group G1 showed lingual displacement tendency, which increased with the protraction angle. The maxillary dentition in Group G2 showed forward displacement, with minimum total and sagittal displacement at 30° (G2-30° total displacement: 0.026mm, sagittal displacement: -0.0245mm). 3. Stress concentration was mainly observed in the zygomaticomaxillary suture and anterior alveolar bone regions in both groups, decreasing as the protraction angle increased. Conclusions Clear aligners combined with protraction can be applied to skeletal Class III patients with mild maxillary deficiency. When the protraction point is located at the distal of canine with a 30° downward and forward angle to the occlusal plane, the maxilla shows forward and downward displacement with minimal labial movement of upper anterior teeth.
    Simulation Study of Fluid Resistance in Different Drafting Positions During Marathon Swimming Competitions
    Qi Yaqian , Sun Kaiyang , Zhan Defeng , Zhang Peng , Fan Xiangbo
    Adopted date: March 10,2025
    [Abstract](7) [HTML](0) [PDF 0.00 Byte](0)
    Abstract:
    Objective: This study employed Computational Fluid Dynamics (CFD) analysis to investigate the fluid resistance characteristics of different drafting positions in marathon swimming, providing theoretical guidance for selecting optimal drafting strategies in competitions and training. Methods: Multi-swimmer models were established using 3D body scanning technology, and different formation models (I-type, A-type, V-type, L-type, and H-type) were created by adjusting the lateral and longitudinal distances between individual swimmers. The ANSYS Discovery Live software was used to simulate the overall resistance of different models and the individual swimmers within the formations. Results: The I3 formation had an overall drag reduction effect, reducing total resistance by 55.21%, while other formations increased overall resistance. The V-type formation had the highest increase in overall resistance (31.88%). During drafting, the position with the least resistance was the end position in the I3 formation; the position with the highest resistance was the middle position in the L-type formation (51.1±18.0 N, P<0.05). During leading, the leading swimmer in the A-type formation (48.2±20.5N) experienced significantly greater fluid resistance than when swimming alone , P<0.05. Conclusion: The drag reduction effect of longitudinal drafting formations was superior, with the end position in a three-person longitudinal arrangement having the best drag reduction effect. Considering both tactics and drag reduction effects, it is advisable to avoid swimming in the middle position of lateral formations.