Hydrogels are an important direction in the field of biomedicine in recent years. Their biocompatibility, biodegradability and biomechanical properties make them ideal materials for the clinical treatment of skin wounds, and they have important research and clinical application values. As a high water content three-dimensional (3D) network structure polymer material with many unique biomechanical shapes, hydrogel has the potential to be applied to skin wounds with many mechanical properties, such as elasticity, viscoelasticity, dynamic stiffness and adhesion, which can not only protect the wound surface after artificial adjustment, but also help to simulate the mechanical microenvironment of biological tissues during healing. Then the function and behavior of cells are regulated to promote cell regeneration, strengthen tissue repair and functional recovery. At the same time, the biomechanical mechanism of skin wound healing is complex, and there are still many challenges in the clinical treatment of skin wounds with hydrogels. Future studies will further focus on the mechanism of biomechanical properties in skin wound healing. In conclusion, hydrogels are expected to be more widely used in the clinical treatment of skin wounds due to their unique mechanical properties. In this review, recent research progress on biomechanical properties of hydrogels is summarized, including regulatory mechanisms and their clinical application in promoting skin wound repair, the importance of studying these properties for the design of tissue engineering scaffold materials is emphasized, and the design, use and clinical transformation of mechanically regulated wound healing is prospeced.