The application of mechanics in clinical wound healing has a long history; however, the systematic underlying mechanisms remain unclear. With recent advancements in biomechanics and mechanobiology, the principles regarding how mechanical factors influence the formation, progression, and healing of wounds have gradually been elucidated. Herein, based on progress in theories, technologies, and clinical practices concerning the interplay between mechanics and wound healing, this study introduces the concept of wound-repairing mechanomedicine. Relevant research is systematically reviewed from the perspectives of biomechanics, mechanobiology, and mechanotherapy. Additionally, potential future development directions are prospectively analyzed to provide novel insights into wound care and strategies for preventing scar formation.