Abstracts：Objective To analyze and compare the strength of titanium alloy crystalline porous scaffold structures and porous scaffolds with three-periodic minimal surface structures, and to explore the effect of porosity on equivalent elastic modulus and permeability.Methods The crystalline porous scaffolds and TPMS porous scaffolds with the same porosity were constructed, and the equivalent modulus of elasticity, equivalent yield strength and permeability of the scaffolds were calculated by using the method of finite element simulation.Results The modulus of elasticity of the eight scaffolds was in the range of 5.1~10.4 GPa, the yield strength was in the range of 69~110 MPa, and the permeability of the four crystalline scaffold was in the range of 1.5×10-8~3.0×10-8 m2.Conclusions With the increase of porosity, the elastic modulus and yield strength of the scaffold gradually decreased and the permeability gradually increased; the cell2-type scaffold is suitable for the repair of defects in load-bearing bone sites because of its higher elastic modulus and yield strength; the cell3-type scaffold with a uniform distribution of stress and a longer linear elasticity phase may be suitable for the design of porous tibial platforms for knee joint prostheses.