Objective Evaluate the mechanical comprehensive performance of the flexible neural electrode with coating modification, which will provide a basis for the optimal design of the electrode and coating parameters. Methods Simplified mechanical models were established for the three processes of contact phase, implantation phase and micromotion phase. The electrode material was polyimide, the coating material was PEG, and PDMS mold injection method was selected as coating method. The coating thickness gradients of 40, 80, 120, 160 and 200 μm were set, and the three factors of buckling force, maximum total deformation and maximum strain of brain tissue were comprehensively evaluated. Results As the thickness increases, the buckling force increases, the maximum total deformation and the maximum strain of the brain tissue decrease, but at the same time, the strain area of the brain tissue increases. For the consideration of three factors of equilibrium, 200 μm is chosen as the optimum thickness of the coating. At this thickness, the buckling force is 0.017 9 N, the maximum total deformation is 0.010 1 mm, and the maximum strain of brain tissue is 0.011 4. Conclusions The thickness of the coating has a great influence on the mechanical properties of the neural electrode. The optimal parameters can be selected by setting the influence factors of the mechanical performance factors under specific case.The optimal parameter selection of coating can improve the performance of electrode, which is of great significance for the clinical application of neural electrode.