Objective: To establish a comprehensive method combining physical model experiment and numerical simulation for studying airflow state of upper respiratory tract.#$NLMethods: Based on CT medical images published online, a 3d model of human upper respiratory tract was reconstructed. Based on 3D printing technology, an experimental model of the upper respiratory tract was established and the flow process of respiration was measured. And a numerical simulation model was created based on the meshing of upper respiratory tract model, and the turbulent realizable k-e model.#$NLResults: First, the numerical simulation was compared with the experimental conditions, and the results were consistent with the experimental results. Furthermore, the airflow in the respiratory process was observed to be in a parabolic shape, and there were air residues in the upper and lower nasal passages during the respiratory exchange process. In addition, the stimulated easily areas in the nasal cavity could be known through the changes in the pressure field and the distribution of vortex structure.#$NLConclusion: The method proposed in this paper, gives full play to the advantages of reliable physical experiments and fine numerical simulation, which is suitable for the study of different respiratory problems, and has application value for clinical personalized medicine.