Risk factors for running injuries can be clustered into intrinsic factors and extrinsic factors. Intrinsic factors include human anatomy, history of previous injuries, sports biomechanics and human neuromuscular control, etc. Extrinsic factors include training method , running shoes and running surfaces, etc. Running surface is considered as one of the most potential risk factors for running injuries. This review summarized the findings on kinematics, kinetics, neuromuscular control and running injuries of lower extremity during running on different surfaces. In general, neuromuscular adjustment may contribute to kinematic adaption during running on different surfaces, and runners can adapt their kinetics and stiffness of lower extremity to achieve similar impact force. However, studies on biomechanical changes during running on different surfaces mainly focus on only one aspect of kinematics, kinetics and neuromuscular regulation. Further studies should focus on three-dimensional biomechanical analysis during running on different surfaces, as well as specific mechanisms of neuromuscular regulation for these biomechanical adjustments.