线粒体的力学生物学研究进展
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Research Progress on Mechanobiology of Mitochondria
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    摘要:

    线粒体是高度动态的细胞器,不仅为细胞提供能量和物质基础,同时参与调控细胞的增殖、迁移、分化和凋亡等。细胞命运受来自微环境的力学信号调节,近年来的研究表明,力学因素对细胞的能量代谢具有调控作用,线粒体作为一个力学感受器和枢纽连接力学和代谢来调控细胞的命运。深入理解力学微环境和线粒体代谢的关系,为促进组织再生和疾病治疗提供有力的指导。本文主要介绍线粒体力学生物学研究进展,并探讨其在组织再生和疾病治疗中的潜在应用。

    Abstract:

    Mitochondria are highly dynamic organelles, which not only provide energy and material basis for cells, but also regulate cell proliferation, migration, differentiation, and apoptosis. Cell fate is regulated by mechanical cues from the microenvironment. Recent studies have shown that energy metabolism is regulated by mechanical cues. Mitochondria can act as mechanical sensors and hubs that connect the mechanics and metabolism to regulate cell fate. A deep understanding of the relationship between the mechanical microenvironment and mitochondrial metabolism provides sufficient guidance for promoting tissue regeneration and treating diseases. In this review, the progression in mitochondrial mechanobiology is mainly introduced and its potential applications in tissue regeneration and disease treatment are explored.

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纳静,郑丽沙,樊瑜波.线粒体的力学生物学研究进展[J].医用生物力学,2024,39(3):545-551

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  • 收稿日期:2023-11-13
  • 最后修改日期:2023-12-12
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  • 在线发布日期: 2024-06-25
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