可降解血管吻合器的结构设计与实验研究
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上海理工大学

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Structure design and experimental study of a novel degradable vascular anastomosis device
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    摘要:

    目的 设计一种新型可降解血管吻合器,探究施压距离与吻合口生物力学性能之间的关系,以提高血管端端吻合的效率与质量。方法 本文设计的吻合器包含左、右内环和外环三个部分,均采用挤压态高纯镁制成,通过建立血管端端吻合的有限元模型,研究在不同施压距离(0.4、0.5、0.6、0.7、0.8 mm)下,血管吻合端面应力分布情况及其变化规律,并通过离体组织吻合实验,研究操作时间、吻合口强度以及组织微观结构的变化。结果 当施压距离为0.6 mm时,吻合口力学性能最优,此时撕脱力为11.79±0.64 N、爆破压为39.32±2.99 kPa,满足临床上对组织吻合口强度的要求,同时组织的机械损伤较小。结论 本文所设计的新型可降解血管吻合器可以通过调节施压距离对组织进行吻合,能够有效提高组织吻合效率,减小组织机械损伤,从而提高吻合质量。因此,本文研究结果可以为可降解血管吻合器的设计提供重要的参考和依据。

    Abstract:

    Objective To improve the efficiency and quality of end-to-end anastomosis, we designed a novel degradable vascular anastomosis device and explored the relationship between the pressure distance and the biomechanical properties of anastomotic stoma. Methods The vascular anastomosis device designed in this study contains three parts: the right and left inner ring, and the outer ring, which all made by extruded high-purity magnesium. The finite element model of end-to-end vascular anastomosis under different pressure distances (0.4, 0.5, 0.6, 0.7 and 0.8 mm) was established to study the stress distribution and its change rules of the anastomosis end face. In vitro experiments were conducted to study the changes of operate time, anastomosis strength and microstructure observation at different pressure distances. Results When the pressure distance was 0.6 mm, the anastomosis tensile force and burst pressure could reach 11.79±0.64 N and 39.32±2.99 kPa, respectively, which meet the clinical requirement for the strength of vascular anastomosis, and with minimal mechanical damage. Conclusion The device designed in this study can used for vascular anastomosis by adjusting the pressure distance which can improve the efficiency of operate, reduce the mechanical damage of tissue and further improve the quality of anastomosis. The research results provide references for the design of degradable vascular anastomosis devices.

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  • 收稿日期:2023-09-28
  • 最后修改日期:2023-11-24
  • 录用日期:2023-11-28
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