针对当前生命与医学研究面对的挑战,分析生命系统在分子、亚细胞、细胞和组织不同尺度的力化耦合行为,并试给出各尺度力化耦合的定量关系。 这些定量关系说明生命系统在各个尺度的结构与它们的力稳态紧密相关,即结构的变化必将导致力稳态的改变;反之,力稳态变化也必将导致结构的变化。 生命系统力稳态的产生源于分子尺度肌球蛋白作用而产生的细胞骨架的收缩张力,并借助生命系统的多级结构实现各级结构的力的自稳态。 因此,力化耦合机制及其定量关系启示研究者可以发展一个从全新角度去认识和治疗疾病的思路和方法,即力医学。最后,讨论力医学认识和治疗疾病的可能路径,为新的医学范式提供诊疗思路和方法。
In view of fundamental challenges to the current life and medical researches, this paper analyzes the mechano-chemical coupling behaviors of living organisms at molecular, sub-cellular, cellular and tissue levels, attempting to explain the quantitative relationships in those mechano-chemical coupling behaviors at different scales. These quantitative relationships show that the structures of living organisms at various scales are closely related to their tensional homeostasis, i. e. , the structural changes will inevitably lead to the changes of tensional homeostasis; Conversely, the changes of the tensional homeostasis will inevitably lead to structural changes. The tensional homeostasis in living organisms stems from contractile force in actin cytoskeleton generated by the action of myosin II at molecular level, and the tensional homeostasis at higher structural levels is realized with the help of hierarchical structures of the living organisms. Therefore, the mechano-chemical coupling mechanisms and their corresponding quantitative relationships inspire scientists to develop a new way of understanding and dealing with diseases, called as mechanomedicine. Finally, the paper discusses possible ways / road maps of mechanomedicine to understand and treat diseases, in order to provide diagnostic and therapeutic ideas for this new medical paradigm.