Objective： To analyze the effects of excitation source location, detection area length and detection depth on human corneal optical coherence elastography (OCE). Methods： In this study, the human eye finite element model with non-uniform distribution of corneal elastic modulus was constructed based on the actual distribution of corneal elastic modulus. By simulating the process of shear wave OCE experiment, the finite element simulation results and theoretical results were compared and analyzed. Results： When the excitation source locations were different, the shear wave velocity errors of the anterior and posterior corneal stroma were different. The shear wave velocities of the anterior and posterior corneal stroma changed nonlinearly when the detection area lengths were different. Under the model of hyperelastic material, the shear wave velocity changed obviously when the detection depths were different. Conclusions： Due to the non-uniform distribution of corneal elastic modulus, the finite element simulation results of shear wave OCE were different at different excitation source locations, different detection area lengths and different detection depths in the anterior and posterior corneal stroma. In OCE experiments, the accuracy of OCE results would be affected if biological tissues with non-uniformity were regarded as homogeneity for measurement.