角巩膜为眼外壁组织,在维持眼球形状和屈光功能方面均发挥着重要作用。 作为典型的黏弹性组织,角巩膜 力学性能的变化会引起相应的眼部疾病,如近视和圆锥角膜等。 临床上,可通过人为改变角巩膜组织的几何结构 (如屈光手术、角膜接触镜的佩戴、角膜胶原交联术)改变生物力学行为,治疗一些与屈光有关的眼科疾病。 本文通 过对与角巩膜相关疾病及临床治疗方法中的生物力学研究进展进行综述,理出这些临床诊疗手段中仍需要解决的 问题,以期为进一步临床诊疗策略的完善和新的潜在治疗手段的开发提供参考。
As the outermost layer of the eyeball, corneal and scleral tissues play an important role in the maintenance of ocular morphology and refraction function. The cornea and sclera are both typical viscoelastic tissues, and changes in their biomechanical properties can lead to corresponding ocular diseases such as myopia and keratoconous. In clinic, biomechanical behavior can be changed by altering the tissue and morphological structures of cornea and sclera ( such as refractive surgery, orthokeratology wear, corneal collagen crosslinking), so as to treat some ocular diseases related to refraction. In this review, the progress of biomechanical researches in corneal and scleral diseases as well as its clinical translation was summarized, and problems in clinic treatments were clarified and discussed, so as to provide references for improving diagnostic and therapeutic strategies, and developing new potential approaches in clinic treatments.