微动刺激幅值对骨组织与钛珠涂层界面的骨生长与微损伤的影响
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中国矿业大学

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Effect of Fretting Stimulation Amplitude on Bone Growth and Micro Injury at the Interface between Bone Tissue and Titanium Bead Coating
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    摘要:

    目的 通过微动力学刺激改善人工关节生物固定界面的性能。方法 以活性大鼠骨组织与非活性钛珠涂层的结合试样作为研究对象,在自制的微动力学刺激试验装置上,探究不同切向微动幅值的力学刺激对固定界面骨组织生长促进作用及骨组织微损伤的影响,揭示微动刺激下骨组织在钛珠涂层表面的促进生长与微损伤机理。结果 微动幅值为40 μm力学刺激组的骨组织与钛珠涂层间的界面结合力最大,切向Ft-D曲线由椭圆形转变为直线形,结合界面处于粘着区,不易产生松动,骨组织结构最完整,钛珠涂层表面黏附生长的组织细胞数量最多,分布范围最广。随着微动幅值的增加,微动刺激对骨生长的促进作用减弱,骨组织与钛珠涂层界面间结合强度逐渐降低,内部空腔区域增多,组织细胞的数量及增殖活性也有不同程度的降低。结论 不同幅值微动刺激对于骨组织的生长促进与微损伤同时存在,最优的微动幅值为40 μm。

    Abstract:

    Objective Improving the performance of biological fixation interface of artificial joint by fretting mechanical stimulation. Methods Taking the bonding sample of active rat bone tissue and inactive titanium bead coating as the research object, on the homemade fretting mechanical stimulation test device, the effects of mechanical stimulation with different tangential fretting amplitudes on the growth promotion and micro injury of bone tissue at the fixed interface were explored, and the mechanism of promoting growth and micro injury of bone tissue on the surface of titanium bead coating under fretting stimulation was revealed. Results The maximum interface bonding force between bone tissue and titanium bead coating is the mechanical stimulation group of 40 μm fretting amplitude. The tangential Ft-D curves change from elliptic to linear, and the bonding interface is in the adhesion area, which is difficult to loose. The bone tissue has the most complete structure, and the number of tissue cells adhering and growing on the surface of titanium bead coating is the largest, as well as the widest distribution range. With the increase of fretting amplitude, the promoting effect of fretting stimulation on bone growth weakened, the bonding strength between bone tissue and titanium bead coating interface gradually decreased, the internal cavity area increased, the number and proliferation activity of tissue cells decreased to varying degrees as well. Conclusions Fretting stimulation with different amplitudes can promote the growth of bone tissue and cause micro injury at the same time, the optimal fretting amplitude is 40 μm.

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  • 收稿日期:2022-05-12
  • 最后修改日期:2022-06-16
  • 录用日期:2022-06-17
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