用于颈动脉风险评估的生物力学参数研究综述
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北京航空航天大学

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A review of biomechanical parameters for carotid risk assessment
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    摘要:

    颈动脉由于其特殊的几何构型以及复杂的流动特性,具有较高的动脉粥样硬化发生风险,各类生物力学参数是对颈动脉进行患病风险评估的有力工具。近半个世纪以来,振荡的低剪切应力环境促进斑块形成这一观点被广泛接受,以此为基础,越来越多的力学指标被提出,例如时均壁面剪切力、剪切振荡系数和相对滞留时间等。本文对剪切力及其时空变化、湍流、血小板运输及活化和血管壁应力集中等生物力学参数进行了介绍,并分析了颈动脉风险评估相关生物力学参数研究的发展趋势,可为更全面、快速的颈动脉风险评估提供理论基础。

    Abstract:

    Carotid is in a high risk of atherosclerosis due to its special geometric features and complex flow characteristics. Various biomechanical parameters are practical tools for carotid risk assessment. In the past half century, it has been widely accepted that oscillatory low shear environment promotes plaque formation. Based on this, more and more biomechanical indexes have been proposed, such as time-average wall shear stress, oscillatory shear index, relative residence time and so on. In this paper, multiple biomechanical parameters are introduced from the perspectives of shear stress and its temporal and spatial variation, turbulence, platelet transport and activation, stress concentration in vascular wall, etc. Their development trends are analyzed to provide a theoretical basis for more comprehensive and rapid carotid risk assessment.

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  • 收稿日期:2022-04-25
  • 最后修改日期:2022-08-25
  • 录用日期:2022-09-15
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