角膜粘弹性对喷气试验的影响分析
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Analysis of the effects of corneal viscoelasticity on air-puff test
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    摘要:

    目的:探索不同条件下角膜粘弹性在喷气试验中的作用。方法:基于患者角膜地形图数据构建个性化全眼模型,加载喷气模型,分析不同条件下线弹性和粘弹性角膜材料喷气试验结果的差异。结果:在角膜刚度、眼内压、巩膜刚度等都相同的情况下,线弹性角膜材料的角膜顶点最大位移比粘弹性小0.01~0.03 mm;当角膜刚度和巩膜刚度一定,眼内压从12 mmHg增大到24 mmHg时,线弹性角膜材料的角膜顶点最大位移绝对值的下降速率比粘弹性慢0.9 μm/mmHg;当角膜刚度和眼内压一定,巩膜刚度从1.24 MPa变化到9.92 MPa时,角膜为线弹性材料的角膜顶点最大位移绝对值的下降速率比粘弹性慢1.1 μm/MPa;当巩膜刚度和眼内压一定,角膜刚度0.827 MPa变化到2.790 MPa时,线弹性角膜材料的角膜顶点最大位移绝对值的下降速率与粘弹性慢8 μm/MPa。结论:喷气试验中的角膜顶点位移主要由角膜组织的弹性驱动,角膜粘弹性在喷气试验中的作用不明显。因此,在临床上采用喷气法评估角膜生物力学响应时可忽略角膜粘弹性影响。

    Abstract:

    Objective:To explore the role of corneal viscoelasticity on air-puff test under different conditions. Methods: Based on the patient's corneal topographic data, a patient-specific model of the whole human eye was constructed, and the air-puff model was loaded. The differences of air-puff test results of linear elastic and viscoelastic corneal materials under different conditions were analyzed. Results: When the corneal stiffness, intraocular pressure and scleral stiffness were all the same, the maximum corneal apical displacement of linear elastic corneal material was 0.01~0.03mm smaller than that of viscoelasticity. With the intraocular pressure increasing from 12 mmHg to 24 mmHg, the decreasing rate of the corneal apical maximum displacement when loaded with linear elastic corneal material was only 0.9 μm / mmHg slower than that when loaded with viscoelastic material. With the corneal stiffness increased from 0.827 MPa to 2.790 MPa, the decreasing rate of the corneal apical maximum displacement when loaded with linear elastic corneal material was only 8 μm/MPa slower than that when loaded with viscoelastic material. With the scleral stiffness increased from 1.24 MPa to 9.92 MPa, the decreasing rate of the corneal apical maximum displacement when loaded with linear elastic corneal material was only 1.1 μm/MPa slower than that when loaded with viscoelastic material. Conclusions: The corneal apical displacement in the air-puff test was mainly driven by the elasticity of the corneal tissue, but the role of corneal viscoelasticity in the air-puff test was not obvious. Therefore, the effect of corneal viscoelasticity can be ignored when air-puff method was used to evaluate corneal biomechanical response.

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  • 收稿日期:2022-04-23
  • 最后修改日期:2022-06-21
  • 录用日期:2022-06-21
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