人体主动脉瓣膜钙化组织力学性质的研究
DOI:
作者:
作者单位:

1.生物力学与力生物学教育部重点实验室,北京市生物医学工程高精尖创新中心,北京航空航天大学生物与医学工程学院;2.首都医科大学附属安贞医院心外科

作者简介:

通讯作者:

中图分类号:

基金项目:


Study on the Mechanical Properties of Calcification from Human Aortic Valve
Author:
Affiliation:

Fund Project:

  • 摘要
  • |
  • 图/表
  • |
  • 访问统计
  • |
  • 参考文献
  • |
  • 相似文献
  • |
  • 引证文献
  • |
  • 资源附件
  • |
  • 文章评论
    摘要:

    目的 主动脉瓣膜钙化组织力学性能对于心脏瓣膜的生物力学研究及病理生理学研究具有重要意义,目前针对动脉粥样硬化、腹主动脉瘤等其他组织内钙化的力学性质有一定研究,但是瓣膜钙化组织力学性质的相关研究比较有限。本文采用纳米压痕测试方法,对人体主动脉瓣取出物的钙化组织的材料力学性能进行了测量。方法 采集了5名主动脉瓣狭窄患者(56.4±5.2岁)的瓣叶取出物,选取钙化瓣叶进行纳米压痕测试,获得钙化组织的弹性模量、硬度等材料力学参数。结果 瓣叶钙化组织的弹性模量为15.69±3.89GPa,硬度为0.59±0.15GPa。结论 通过纳米压痕测量方法,得到了瓣叶钙化组织的弹性模量和硬度,为瓣膜的生物力学研究提供实验数据参考。

    Abstract:

    Objective The mechanical properties of the calcified aortic valve tissue are important for the biomechanical and pathophysiological studies of the heart valve. At present, studies on the mechanical properties of the calcified valve tissue are limited while the studies on the calcification mechanical properties in atherosclerosis or abdominal aortic aneurysms are abundant. The mechanical properties of calcified tissue from human aortic valve were measured by nanoindentation test in this study. Methods Leaflets from 5 patients with aortic stenosis (56.4±5.2 years old) were collected. Elastic modulus and hardness of the calcified leaflets were obtained by nanoindentation. Results The elastic modulus and hardness of the calcified leaflets tissue were 15.69±3.89 GPa and 0.59±0.15 GPa respectively. Conclusions The elastic modulus and hardness of the calcified valve tissues were obtained by the nanoindentation, which provided experimental data for the valve biomechanical research.

    参考文献
    相似文献
    引证文献
引用本文
分享
文章指标
  • 点击次数:
  • 下载次数:
  • HTML阅读次数:
  • 引用次数:
历史
  • 收稿日期:2020-10-30
  • 最后修改日期:2021-01-18
  • 录用日期:2021-01-19
  • 在线发布日期:
  • 出版日期: