载荷作用下骨细胞分泌因子对成骨细胞和破骨细胞的调节
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桂林医学院

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国家自然科学基金项目(No.31660261)和广西区自然科学基金(2018GXNSFAA281357)


Regulation of osteoblasts and osteoclasts by secretory factors derived from osteocytes under mechanical loading
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Guilin Medical University

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    摘要:

    骨细胞是骨组织主要的力学感受及转导细胞,它们通过众多突触结构相互连接,形成庞大的骨稳态细胞调控网络,联系着成骨细胞、破骨细胞等骨基质表面细胞。骨细胞通过旁分泌途径影响成骨细胞骨形成和破骨细胞骨吸收来调节骨代谢,维持骨更新。本文就骨细胞在受到力学刺激后分泌或释放的一些信号分子或蛋白因子对成骨细胞和破骨细胞生长分化的影响,综述了近年来关于受力学刺激的骨细胞是如何与成骨细胞及破骨细胞进行通讯的,以期为骨细胞生物力学方面的研究提供新思路。

    Abstract:

    Osteocytes are the main mechanical sensory and transductive cells of bone tissue. They connect with each other through many synaptic structures to form a huge regulatory network of bone steady-state cells, which are connected with osteoblasts, osteoclasts and other bone matrix surface cells. Osteocytes regulate bone metabolism and maintain bone regeneration by affecting osteoblast bone formation and osteoclast bone resorption through paracrine pathway. This paper focuses on the effects of some signal molecules or protein factors secreted or released by osteocytes after mechanical stimulation on the growth and differentiation of osteoblasts and osteoclasts. In this review, we discuss recent advances investigating how mechanically stimulated osteocytes communicate with osteoblasts and osteoclasts, providing a new ideas for the study of osteocytes biomechanics.

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历史
  • 收稿日期:2020-07-16
  • 最后修改日期:2020-09-01
  • 录用日期:2020-09-10
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