基质刚度调节细胞-细胞外基质间黏附对肿瘤细胞迁移影响的模型研究
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作者单位:

1.太原理工大学;2.中北大学

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基金项目:

国家自然科学基金项目(面上项目,重点项目,重大项目)


The modeling study of influence of cell-ECM adhesion on migration of tumor cells regulated by ECM stiffness
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Affiliation:

1.taiyuan university of technology;2.North University of China

Fund Project:

The National Natural Science Foundation of China (General Program, Key Program, Major Research Plan)

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    摘要:

    摘要:目的 研究细胞外基质刚度的改变对细胞和细胞外基质间黏附及肿瘤迁移的的影响。方法 建立基于网状波茨模型(cellular pottsmodel,CPM),模拟肿瘤细胞的生长与细胞间免疫反馈过程,观察细胞力学行为的改变对细胞-细胞外基质粘附的影响状况,分析不同细胞外基质下,肿瘤细胞迁移的变化。结果 细胞与细胞外基质的粘附力大小会影响肿瘤细胞的迁移速度。同时,细胞外基质刚度的改变调节细胞与细胞外基质的粘附力大小,细胞外基质刚度的增加使粘附分子浓度增加,从而降低了肿瘤细胞的迁移速度。结论 模拟结果表明,细胞的迁移和分布模式与细胞外基质的粘附性和细胞外基质的刚度密切相关。增加细胞外基质的刚度能有效地控制肿瘤细胞的迁移速度,这些结果可进一步揭示细胞外基质的动态变化、粘附大小及肿瘤细胞迁移的力学表现。

    Abstract:

    Abstract: Objective To study the influence of cell-ECM adhesion on migration of tumor cells regulated by ECM stiffness. Method The cellular Potts model (CPM) was established to simulate the procession of tumor cells and the cellular immune feedback system, the effects of cell mechanical behavior on cell-extracellular matrix adhesion were observed, and the migration of tumor cells under different extracellular matrix was analyzed. Results Under the different cell-matrix adhesion, tumor cells could migrate at different speeds. At the same time, the change of extracellular matrix stiffness regulates the adhesion force between cells and matrix. With the increase of extracellular matrix stiffness, the concentration of adhesion molecules raised, which reduced the migration rate of tumor cells. Conclusions The results show that the migration and distribution patterns of cells are closely related to the adhesion and stiffness of extracellular matrix. Increasing the stiffness of extracellular matrix can effectively control the migration rate of tumor cells. These findings may further reveal the dynamic changes of extracellular matrix, the size of adhesion and the mechanical manifestation of tumor cells migration.

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  • 收稿日期:2020-07-14
  • 最后修改日期:2020-09-05
  • 录用日期:2020-09-10
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