力学刺激在椎体软骨终板退变中的作用及机制
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1.北京大学第三医院;2.教育部骨与关节精准医学工程研究中心;3.北京脊柱疾病重点实验室

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国家自然科学基金项目(面上项目,重点项目,重大项目)


The Role and Mechanisms of Mechanical Stimulation in Degeneration of Vertebral Cartilage Endplates
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Affiliation:

1.Peking University Third Hospital;2.Engineering Research Center of Bone and Joint Precision Medicine, Ministry of Education;3.Beijing Key Lab of Spine Diseases

Fund Project:

The National Natural Science Foundation of China (General Program, Key Program, Major Research Plan)

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    摘要:

    终板的重要功能是帮助椎间盘传递应力和供给营养,终板的退变可能会诱发或促进椎间盘退变,引起一系列严重影响人们健康和生活质量的脊柱疾患。终板软骨细胞可以感受力学刺激,力学刺激是影响终板退变的重要因素,不适宜的力学刺激会加速终板退变。本综述回顾了力学刺激对终板软骨细胞凋亡、合成抑制、钙化及细胞外基质降解诸方面的影响,并总结了力学刺激导致椎体终板退变的相关机制。力学刺激诱发的终板退变是由各种信号转导因子构成的复杂信号通路网络精细调节。本综述主要涉及到的信号通路包括NF-κB信号通路、Wnt信号通路、Hedgehog信号通路、MAPK信号通路、RhoA/Rock-1信号通路、AKT/mTOR信号通路、TGF-β信号通路和miRNA相关信号通路。同时,对这些通路相互联系进行了梳理总结。总结显示,多个信号通路可以共同作用调节终板软骨细胞代谢,并导致终板退变。通过相关机制系统回顾,希望给终板退变早期诊断及针对性治疗带来有益的启示。

    Abstract:

    The important function of the endplate is to help the intervertebral disc to transmit stress and supply nutrition. Endplate degeneration might induce or promote degeneration of the intervertebral disc, causing a series of spine diseases that seriously impair people's health and life quality. Endplate chondrocytes can respond to mechanical stimulation, which is an important factor affecting endplate degeneration. Inappropriate mechanical stimulation will accelerate endplate degeneration. This review summarized the effects of mechanical stimulation on vertebral endplate chondrocyte apoptosis, synthesis inhibition, calcification, and extracellular matrix degradation. The endplate degeneration induced by mechanical stimulation is regulated by a complex network of signal pathways composed of various signal transduction factors. The signal pathways involved in this review included NF-κB signaling pathway, Wnt signaling pathway, Hedgehog signaling pathway, MAPK signaling pathway, RhoA/Rock-1 signaling pathway, AKT/mTOR signaling pathway, TGF-β signaling pathway and miRNA related signals. The interconnection of these pathways was highlighted and summarized. The review showed that multiple signaling pathways work together to regulate endplate chondrocyte metabolism, which ultimately leads to endplate degeneration. This review might shed light on early diagnosis and precise treatment of cartilage endplate degeneration.

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历史
  • 收稿日期:2020-07-07
  • 最后修改日期:2020-08-13
  • 录用日期:2020-08-24
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