Abstract：Objective Evaluate the damage of von Willebrand Factor (vWF) induced by shear stress in BPX-80 centrifugal blood pump, and determine whether it can be used as a reference pump for vWF injury research, so as to provide some guidance for vWF damage evaluation. Method An in vitro hemolysis test platform was established according to the ASTM standards. The BPX-80 centrifugal blood pump was tested for 8 hours by using fresh porcine blood. The hemolysis level and von Willebrand Factor (vWF) damage of hourly blood samples were then evaluated and compared with the static control group. Results The hemolysis index of BPX-80 is stable and low during the 8-hour-test. The level of free hemoglobin in the first 6 hours is not significantly different from that of the static control group; the high molecular weight vWF polymer has a small amount of degradation, and shows no significant difference compared with the static control group; there is no significant change in the concentration of vWF antigen, which was basically consistent with the trend of the static control group. Conclusions It shows that the BPX-80 centrifugal blood pump has good blood compatibility and can be used as a reference pump for vWF damage and hemolysis evaluation, thereby providing guidance for the design and optimization of new blood pumps to reduce clinical gastrointestinal bleeding complications.