材料和孔隙率对可降解骨支架内骨成形的影响
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1.武汉理工大学机电工程学院;2.华中科技大学同济医学院

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R 318.01

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国家重点研发计划项目


The effect of materials and porosity on bone formation of degradable bone scaffolds
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1.School of Mechanical and Electrical Engineering,Wuhan University of Technology;2.Tongji Medical College,Huazhong University of Science & Technology

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    摘要:

    目的 研究可降解骨支架植入人体后的骨修复,不同材料和孔隙率对于支架内骨成形的影响。方法 根据骨折愈合自然反应机理,运用有限元方法,结合支架几何结构,搭建了以材料降解曲线和骨重建控制方程为基础的计算耦合模型。通过这一平台,选择了五种材料和四种孔隙率的支架代表性体积元进行计算模拟分析,并通过骨密度和支架最大应力这两个参数来反应这一动态过程。结果 材料的弹性模量对于支架内骨组织的生长的影响较大,材料的弹性模量越小,骨成形量越大,但会对支架的力学性能造成较大影响。较高孔隙率的支架刚度小,能够更好的促进骨组织的形成,但同时也会破坏支架的力学稳定性。结论 根据不同年龄、性别和部位骨组织的性能需求,为可降解多孔骨支架的材料和孔隙率选择,结构设计以及临床应用提供个性化参考和计算依据。

    Abstract:

    Objective To study the effect of different materials and porosity on the bone formation in the scaffold after the degradable bone scaffold is implanted into the human body. Methods According to the natural reaction mechanism of fracture healing, a finite element method was used, combined with the geometry of the scaffold, to establish a computationally coupled model based on the material degradation curve and the bone reconstruction control equation. Through this platform, five kinds of materials and four types of porosity representative volume elements of the scaffold were selected for calculation and analysis, and the dynamic process was reflected by the two parameters of bone density and maximum stress of the scaffold. Results The elastic modulus of the material has a greater influence on the growth of bone tissue in the stent. The smaller the elastic modulus of the material, the greater the amount of bone formation, but it will have a greater impact on the mechanical properties of the stent. The scaffold with higher porosity has lower rigidity, which can better promote the formation of bone tissue, but at the same time, it will also destroy the mechanical stability of the scaffold. Conclusions According to the performance requirements of different age, gender and location of bone tissue, it provides personalized reference and calculation basis for the selection of materials and porosity, structural design and clinical application of degradable porous bone scaffolds.

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  • 收稿日期:2020-06-30
  • 最后修改日期:2020-08-27
  • 录用日期:2020-09-10
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