生物材料功能化表面对巨噬细胞极化调控的研究进展
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1.天津医科大学总医院骨科;2.天津医科大学总医院核医学科;3.军事科学院系统工程研究院卫勤保障技术研究所;4.天津市口腔医院

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国家自然科学基金资助项目(31470935、11432016)


Research progress on the regulation of macrophage polarization by biomaterial functionalized surface
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1.Department of orthopedics,Tianjin Medical University General Hospital;2.Department of Nuclear Medicine, Tianjin Medical University General Hospital,;3.Institute of Medical Service Support,Institute of Systems Engineering,Academy of Military Sciences;4.Tianjin Key Laboratory of Oral and Maxillofacial Function Reconstruction,Tianjin Stomatological Hospital,The Affiliated Stomatological Hospital of Nankai University

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    摘要:

    假体松动及假体周围炎作为骨关节炎(OA)关节置换假体植入物手术术后的严重并发症,常需要二次手术进行修复,易对患者身心健康及经济状况产生不利影响。越来越多的研究表明:巨噬细胞受不同刺激所表达的功能表型即巨噬细胞极化状态,延长的M1极化可导致长期炎症的延续,及时有效的M2巨噬细胞的表型会增强骨生成和组织重塑细胞因子分泌以及随后的骨整合,对假体松动及假体周围炎的发展与转归起着至关重要的作用。细胞外基质局部微环境作为巨噬细胞的活化、迁移、增殖与融合的重要影响因素,研究者主要通过生物材料的表面性能(表面形貌、润湿性、化学组成,生物蛋白)同巨噬细胞之间的串扰联系对其认识及深入了解。巨噬细胞作为一种效应细胞,能够通过对生物材料植入人体后与生理环境接触形成的理化环境进行感知,同时做出复杂的时空间细胞功能响应。本文就近些年巨噬细胞极化与材料表面性能相关发现做一总结与归纳。

    Abstract:

    Prosthetic loosening and periprosthetic inflammation, as serious complications after osteoarthritis (OA) joint replacement prosthesis implant surgery, often require secondary surgery for repair, which is easy to adversely affect the physical and mental health and economic status of patients.More and more studies have shown that the functional phenotype expressed by macrophages by different stimulites, namely macrophage polarization state, prolonged M1 polarization can lead to the continuation of long-term inflammation, timely and effective M2 macrophage phenotype will lead to enhanced osteogenesis and tissue remodeling cytokine secretion curve and subsequent osseointegration, which play a crucial role in the development and outcome of prosthetic loosening and periprosthetic inflammation.The local microenvironment of ECM (extracellular matrix) is an important factor in the activation, migration, proliferation and fusion of macrophages. Researchers have deeply understood it mainly through the crosstalk between the surface properties of biomaterials and macrophages. As an effector cell, macrophages can perform complex spatiotemporal cellular functional responses by sensing the physical and chemical environment (surface topography, wettability, chemical composition, biological proteins) represented by the surface properties of biomaterials.This paper summarizes the recent findings on macrophage polarization and material surface properties.

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  • 收稿日期:2020-06-27
  • 最后修改日期:2020-07-25
  • 录用日期:2020-07-28
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