聚ε-己内酯(PCL)小口径人造血管在动物实验中的内皮化现状
DOI:
作者:
作者单位:

北京航空航天大学生物与医学工程学院 生物力学与力生物学教育部重点实验室

作者简介:

通讯作者:

中图分类号:

R318.08

基金项目:

国家自然科学(11772036,31870940)


Endothelialization of poly ε-caprolactone (PCL) small-caliber vascular graft implanted in animals
Author:
Affiliation:

Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education,School of Biological Science Medical Engineering,Beihang University,Beijing

Fund Project:

  • 摘要
  • |
  • 图/表
  • |
  • 访问统计
  • |
  • 参考文献
  • |
  • 相似文献
  • |
  • 引证文献
  • |
  • 资源附件
  • |
  • 文章评论
    摘要:

    体内植入人造血管后所面临的最严重的问题就是血管内血栓的形成,为了解决这一问题,多年来,科学界进行了各种尝试,然而,解决血栓形成,使血管保持长期通畅的根本方法是实现内皮化。内皮化的方法有两种,一种是内皮细胞体外种植法,此种方法种植的内皮细胞抗血流切应力能力极弱,植入后大部分的内皮细胞会被血流冲掉;此外,细胞的体外扩增和种植往往需要花费大量时间,且过程中极易被微生物污染,使得其在临床紧急事件的应用变得不切实际。第二种是内皮细胞的在体内皮化,这种方法在动物实验(犬、猪、羊、兔、大鼠等)上已然取得不错效果。然,仍无法解决临床植入后,急性血栓形成的问题。聚ε-己内酯(PCL)凭借其可生物降解,成本低,具备良好的力学性能等优势,近年来广泛应用作组织工程支架、药物输送、人造血管等。在对其做简要的介绍后,本文主要对PCL小口径人造血管在动物实验中的内皮化研究现状进行综述。

    Abstract:

    The most serious problem after implantation of vascular graft is the formation of intravascular thrombus. In order to solve this problem, the scientific community has made various attempts over the past years. However, the fundamental way to resolve this problem to keep the vascular open for a longer period is endothelialization. There are two ways to realize endothelialization. One is implanting endothelial cells in vitro. Nevertheless, cells after implanting are always too weak to sustain blood flow, thus most of the cells will be washed away. Furthermore, cells culturing and implanting are always time-consuming and during this process contamination is easy to happen. Therefore, this method is not feasible in clinic emergency. The second way is in vivo endothelialization. This method succeeded in animal models including dog, pig, sheep, rabbit and rat. Unfortunately, it stays a problem in clinic. Poly (ε-caprolactone) as a degradable material show good biomechanical behavior and has been widely used in tissue engineering, drug delivery, and artificial grafts. After giving a brief introduction of PCL, this article reviews the current status of endothelialization for PCL small-diameter vascular graft implanted in healthy / pathological animals.

    参考文献
    相似文献
    引证文献
引用本文
分享
文章指标
  • 点击次数:
  • 下载次数:
  • HTML阅读次数:
  • 引用次数:
历史
  • 收稿日期:2020-06-08
  • 最后修改日期:2020-08-11
  • 录用日期:2020-08-24
  • 在线发布日期:
  • 出版日期: