新生婴儿与老年人红细胞力学特性对比实验研究
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1.上海交通大学;2.上海交通大学医学院附属新华医院 普外科;3.昆山杜克大学,数据科学系;4.上海交通大学 工程力学系;5.昆山杜克大学,数学系

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国家自然科学基金项目(11872040),国家重点研发计划政府间国际科技创新合作重点专项(2017YFE0117100)


Comparative experimental study on the mechanical properties of red blood cells from newborn babies and elderly people
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1.Shanghai Jiao Tong University;2.Department of General Surgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine;3.Department of Data Science,Kunshan Duke University;4.Department of Engineering Mechanics, Shanghai Jiao Tong University;5.Department of Engineering Mechanics, Shanghai Jiao Tong Universit;6.Department of Mathematics ,Kunshan Duke University

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    摘要:

    目的 通过比较新生婴儿与80岁以上老年人红细胞力学特性(细胞表面积,体积和弹性模量)及与总胆固醇、糖化血红蛋白等生理生化参数的相关关系,分析不同年龄和生化参数对红细胞力学特性的影响。 方法 采用微量吸管技术测量新生婴儿和80岁以上老年人的红细胞的表面积、体积和弹性模量,采用统计分布分析、相关性分析和回归分析来进行数据分析。 结果 80岁以上老年人红细胞的体积、表面积、弹性模量均值都比新生婴儿的红细胞相应参数要小,同年龄组内的单个人样本间的红细胞力学参数均值相差不大。新生儿红细胞几何参数分布与老人相比更为集中,而弹性模量分布比老年人红细胞的更分散。新生婴儿的红细胞力学特性与总胆固醇和出生孕周相关性高;老年人的红细胞力学特性与舒张压和糖化血红蛋白的相关性高。结论 新生婴儿与80岁以上老年人的红细胞力学特性有明显差异,影响不同年龄的红细胞力学特性的生化指标也不同。

    Abstract:

    Object By comparing the mechanical properties (cell area, volume and elastic modulus) of red blood cells between newborn babies and the elderly over 80 years old, and the correlation with the physiological and biochemical parameters such as total cholesterol and glycosylated hemoglobin, the effects of different ages and biochemical parameters on the mechanical properties of red blood cells were analyzed. Methods The Micropipette aspiration was used to measure the surface area, volume and elastic modulus of erythrocytes of newborn babies and elderly people over 80 years old, and the data were analyzed by statistical distribution analysis, correlation analysis and regression analysis. Results The mean values of volume, surface area and elastic modulus of red blood cells in the elderly over 80 years old were smaller than those in the newborn babies, and the mean values of mechanical parameters of red blood cells in the same age group were not significantly different. The geometric parameter distribution of erythrocytes of newborns is more concentrated than that of the elderly, while the distribution of elastic modulus is more dispersed than that of the elderly.The mechanical properties of red blood cells in newborn babies are highly correlated with total cholesterol and gestational week; the mechanical properties of red blood cells in elderly people are highly correlated with diastolic blood pressure and glycated hemoglobin. Conclusion There are significant differences in the mechanical properties of red blood cells between newborn babies and the elderly over 80 years old, and the biochemical indexes that affect the mechanical properties of red blood cells at different ages are also different.

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  • 收稿日期:2020-05-09
  • 最后修改日期:2020-07-31
  • 录用日期:2020-07-31
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