可注射封闭性水凝胶力学性质与其止血性能的相关性
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国家自然科学基金面上项目(81871827),深圳市基础研究项目 (GJHZ20170314154914747,JCYJ20170818155915362,GJHS20170314153933234)


The Correlation between Mechanical Properties and Hemostatic Ability of Injectable Sealing Hydrogels
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    摘要:

    目的 探究封闭性水凝胶力学性质与其止血性能之间的关系。方法 通过测量透明质酸/明胶水凝胶凝固时间、弹性模量、黏性模量、顶破强度和止血性能,与医用纤维蛋白胶止血剂对比,提出凝固时间和力学参数,用于判断封闭性水凝胶应用于临床止血的可行性。结果 凝固时间长以及弹性模量、黏性模量和顶破强度小的水凝胶只可能对小出血量起控制作用,凝固时间短、弹性模量、黏性模量和顶破强度大的水凝胶能有效减少大出血量情况下的血液损失。结论 水凝胶的凝固时间、弹性模量、黏性模量以及顶破强度与其止血性能有关,如果水凝胶封闭止血要达到纤维蛋白胶的止血水平,其凝固时间应小于120 s,弹性模量大于600 Pa,黏性模量大于120 Pa;对于直径2 mm的组织模型破损,顶破强度要不低于10.7 kPa,最好高于16.0 kPa。

    Abstract:

    Objective To investigate the correlation between mechanical properties and hemostatic ability of the sealing hydrogels. Methods The gelation time, elastic modulus, viscous modulus, bursting strength and hemostatic ability of the hyaluronic acid/gelatin hydrogels were measured. Compared with fibrin sealant, gelation time and mechanical parameters were proposed to judge the feasibility of sealing hydrogels to be used for hemostasis in clinic. Results Hydrogels with a long gelation time, low elastic modulus, low viscous modulus and small bursting strength were merely suitable for hemostasis in minor bleeding. The hydrogels with short gelation time, high elastic and viscous modulus and large bursting strength could effectively reduce the blood loss in the cases of massive bleeding. Conclusions The hemostatic ability of a hydrogel was correlated to its gelation time, elastic modulus, viscous modulus and bursting strength. To achieve hemostasis as effective as fibrin sealant, the gelation time of a sealing hydrogel should be less than 120 s, its elastic and viscous modulus should exceed 600 Pa and 120 Pa, respectively. For the damage with diameter of 2 mm in the tissue model, the burst strength should exceed 10.7 kPa and preferably be larger than 16.0 kPa.

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骆井万,范海明,刘畅,孙雨龙.可注射封闭性水凝胶力学性质与其止血性能的相关性[J].医用生物力学,2020,35(4):496-501

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  • 收稿日期:2019-05-06
  • 最后修改日期:2019-08-25
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  • 在线发布日期: 2020-08-17
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