基于病理切片的延髓-上颈髓三维有限元模型的建立及其损伤的生物力学分析
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1.北京工商大学;2.北京工商大学 材料与机械工程学院;3.中国人民解放军总医院 神经外科

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国家自然基金科学项目(81571350)


Establishment of three-dimensional finite element model of medulla oblongata-upper cervical spinal cord based on pathological section and biomechanical analysis of injury
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1.Beijing Technology and Business University;2.School of Materials Science and Mechanical Engineering, Beijing Technology and Business University;3.Chinese PLA General Hospital, Neurosurgery

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    摘要:

    目的 建立基于标本病理切片数据的具有细致灰质核团和白质纤维束分界线的延髓-上颈髓三维实体模型,通过有限元分析获得延髓-上颈髓受齿状突压迫情况下的应力、应变水平,为临床研究提供参考。方法 运用Mimics对切片数据进行处理,建立点云模型;运用SolidWorks对点云模型进行定位、编辑、优化,建立三维实体模型;运用HyperMesh建立有限元模型并运用ANSYS进行有限元分析。结果 建立了具有明确灰质、白质界线以及白质纤维束质的延髓-上颈髓模型;得到了不同压迫程度下白质和灰质的应力、应变水平以及应力-应变对比曲线。结论 结合标本病理切片和逆向工程能够建立具有灰质、白质清晰形态和结构的三维延髓-上颈髓模型;延髓-上颈髓受压时灰质的应力水平都小于白质,20%左右的压迫程度是白质的临界状态,当病情发展超过临界状态时,白质生物力学性能可能失效,由此引起灰质的损伤。

    Abstract:

    Objective A three-dimensional solid model of medulla oblongata-superior cervical spinal cord with fine gray matter nucleus and white matter fiber bundle dividing line based on specimen pathological section data was established, and the stress and strain levels of medulla oblongata-superior cervical spinal cord under dentate process compression were obtained by finite element analysis to provide reference for clinical research. Methods Mimics is used to process the slice data to establish the point cloud model; SolidWorks is used to locate, edit and optimize the point cloud model to establish a three-dimensional solid model; HyperMesh is used to establish the finite element model and ANSYS is used for finite element analysis. Results A medulla oblongata-superior cervical spinal cord model with clear boundary between gray matter and white matter and white matter fiber bundle was established, and the stress and strain levels and stress-strain contrast curves of white matter and gray matter under different compression degrees were obtained. Conclusions Combined with pathological sections of specimens and reverse engineering, a three-dimensional medulla oblongata-superior cervical spinal cord model with clear morphology and structure of gray matter and white matter can be established; when the medulla oblongata-superior cervical spinal cord is compressed, the stress level of gray matter is less than that of white matter, and about 20% of the degree of compression is the critical state of white matter. when the disease develops beyond the critical state, the biomechanical properties of white matter may fail, resulting in gray matter damage.

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  • 收稿日期:2020-03-27
  • 最后修改日期:2020-05-16
  • 录用日期:2020-05-21
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