斑块偏心率对可降解聚乳酸支架植入狭窄血管的影响研究
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1.上海理工大学;2.上海百心安生物技术有限公司;3.上海心玮医疗科技有限公司

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上海工程技术研究中心资助项目(18DZ2250900)


Effect of plaque eccentricity on biodegradable polylactic acid stent implantantion in stenotic vessels
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1.University Of Shanghai For Science And Technology;2.Shanghai stroke care technology Co., Ltd

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    摘要:

    目的:研究支架在植入狭窄血管后,斑块偏心率对支架性能以及血管和斑块应力分布的影响。方法:运用Solid Works软件构建支架和理想化狭窄血管模型,赋予斑块4种不同的偏心率(0%、20%、40%、60%),采用有限元方法分析支架扩张至目标位移时,支架的径向回弹率和轴向缩短率、血管和斑块的应力变化情况。结果:随着斑块偏心率的增加,支架的径向回弹率和轴向缩短率都逐渐增大。同时,血管和斑块的应力也呈递增趋势且高应力区域都逐渐靠近狭窄侧一端,斑块的最大von Mises等效应力远大于动脉。结论:斑块偏心率对支架性能以及狭窄血管的应力分布有一定影响,在支架设计中,应对斑块的几何形状予与考虑,以改善支架在介入治疗中的临床效果。

    Abstract:

    Objective:To study the effect of plaque eccentricity on the stent performance and stress distributions of artery and plaque during implantation process of stent in stenotic vessels. Method:Solid Works software was used to construct the stent and idealized stenotic vessels, and attached 4 different eccentricities (0%, 20%, 40%, 60%) to the plaque. Then finite element method was used to analyze the stent recoil,stent foreshortening, and stress distributions of artery and plaque when the stent was expanded to the target displacement. Result:Along with the increase of plaque eccentricity, both stent recoil and stent foreshortening gradually grew. At the same time, the stress of artery and plaque also showed an increasing tread, and high-stress areas gradually approached the narrow side. The maximum von Mises stress of the plaque was much greater than that of the artery. Conclusions:Plaque eccentricity had a certain effect on the performance of the stent and the stress distribution of stenotic vessels. In the design of the stent, the geometry of the plaque should be considered to improve the clinical effect of the stent in interventional treatment.

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  • 收稿日期:2020-03-10
  • 最后修改日期:2020-04-21
  • 录用日期:2020-04-23
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