用AFM 探究食管组织在纳米尺度下的硬度性能
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西南交通大学 摩擦学研究所

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国家自然科学基金(51675447)


Study on the hardness of esophageal tissues at nanoscale using atomic force microscopy
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1.Tribology Research Institute,Southwest Jiaotong University,Cheng du 610031;2.China

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    摘要:

    目的:随着对生物学、纳米科学等领域研究的不断深入,原子力显微镜(AFM)越来越多地被用于生物材料领域。通过原子力显微镜可以揭示纳米尺度下生物组织的力学性能,而这些微观力学性能也常用作组织生理状态与功能的标志。方法:本文以猪食管作为实验材料,借助AFM研究了不同加载率,压入深度及停留时间下食管组织的硬度性能。结果:食管组织在纳米尺度下的硬度值与加载率及压入深度呈现出强相关性,硬度值随着加载率的增大而增大,而随着压入深度的增加而减小。食管组织硬度性能的差异性与食管组织的粘弹性及粘塑性相关,主要包括接触应力、能量转换及应变塑性梯度等。结论:实验结果对于临床诊断、手术操作及人工材料开发将具有重要的意义,从微观尺度上揭示了食管组织的力学性能变化规律。

    Abstract:

    Objective: With the depending research in biology, nanoscience and other fields, atomic force microscopy (AFM) is increasingly used in the field of biomaterials. AFM can reveal the mechanical properties of biological tissues at the nanoscale, which are often used as indicators of the physiological state and function of tissues. Methods: In this paper, the porcine esophagus was chosen as experimental sample to study the hardness properties of esophageal tissues at different loading rates, deflection and dwell time with AFM. Results: The results showed that the hardness of esophageal tissues at the nanoscale was strongly correlated with the loading rate and the deflection, which increased with the increasing loading rate and decreased with the increasing deflection of cantilever. The difference in the hardness was associated with the viscoelasticity and viscoplasticity of esophageal tissues, including contact stress, energy transition and strain plastic gradient. Conclusions: The results have important significance for clinical diagnosis, surgical operation and artificial material development, and reveal the changing law of the mechanical properties of the esophageal tissues from the microscale.

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  • 收稿日期:2020-03-10
  • 最后修改日期:2020-04-23
  • 录用日期:2020-04-23
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