微小RNA在力相关牙周炎症反应和组织改建中的作用
DOI:
作者:
作者单位:

1. 上海交通大学医学院附属第九人民医院•口腔医学院 口腔修复科;2. 国家口腔疾病临床医学研究中心;3. 上海市口腔医学重点实验室,上海市口腔医学研究所

作者简介:

通讯作者:

中图分类号:

基金项目:

国家自然科学(31470903,31270991,30900282),上海市浦江人才计划项目(13PJD021),上海市青年科技启明星计划(A类)项目(10QA1404200)。


The role of microRNA in force-related periodontal inflammatory response and tissue remodeling
Author:
Affiliation:

1. Department of Prosthodontics,Shanghai Ninth People’s Hospital,College of Stomatology, Shanghai Jiao Tong University School of Medicine;2. National Clinical Research Center for Oral Diseases;3. Shanghai Key Laboratory of Stomatology &4.Shanghai Research Institute of Stomatology

Fund Project:

  • 摘要
  • |
  • 图/表
  • |
  • 访问统计
  • |
  • 参考文献
  • |
  • 相似文献
  • |
  • 引证文献
  • |
  • 资源附件
  • |
  • 文章评论
    摘要:

    微小RNA(microRNA,miRNA)是一种非编码单链RNA分子,可通过抑制靶基因mRNA的翻译来调控生物体遗传信息表达,参与体内多种生物学过程的发生发展。在机械力诱导机体产生的炎症性疾病和组织改建中也存在miRNA的身影。牙周组织中机械力敏感细胞可在力作用下导致牙周组织炎症反应、组织改建等病理/生理性变化,在这一过程中miRNA可能通过抑制这些细胞中特定基因的翻译,对力相关牙周炎症和组织改建的发生发展起到重要的调控作用。本文对miRNA在力相关炎症反应和组织改建,尤其是牙周炎症反应和组织改建中的作用做一综述。

    Abstract:

    miRNA is a kind of non-coding single-stranded RNA, which can regulate the expression of genetic information by inhibiting mRNA translation of the target gene and participate in the occurrence and development of a variety of biological processes in vivo. miRNAs also take part in inflammatory diseases and tissue remodeling induced by mechanical forces. Mechanosensitive cells in periodontal tissue can lead to pathological/physiological changes such as periodontal inflammatory response and periodontal remodeling. miRNAs might have played important roles in the occurrence and development of force-related periodontal inflammatory diseases and tissue remodeling, by inhibiting the translation of specific genes in these cells. This article reviews the roles of miRNAs in force-related inflammatory response and tissue remodeling, especially in periodontal inflammatory response and tissue remodeling.

    参考文献
    相似文献
    引证文献
引用本文
分享
文章指标
  • 点击次数:
  • 下载次数:
  • HTML阅读次数:
  • 引用次数:
历史
  • 收稿日期:2020-03-06
  • 最后修改日期:2020-05-05
  • 录用日期:2020-05-06
  • 在线发布日期:
  • 出版日期: