1.Shanghai University of Medicine &2.Health Sciences;3.University of Shanghai for Science and Technology
目的 设计并研制壁冠状动脉周向应力体外模拟装置，实现不同程度心肌桥压迫下壁冠状动脉周向应力的体外加载。方法 利用心肌桥冠状动脉血液动力学体外模拟装置，实现壁冠状动脉周向应力的体外测量。依托上述实验数据实现不同程度心肌桥压迫下壁冠状动脉周向应力的体外加载。结果 通过体外测量实验发现：壁冠状动脉近心段周向应力最大值、平均值以及波动值都会随着心肌桥压迫程度的增加而显著增大。通过壁冠状动脉周向应力的体外加载实验，验证加载波形与周向应力体外测量实验波形基本吻合。 结论 装置可以实现壁冠状动脉周向应力的体外加载，为探究壁冠状动脉近端血液动力学异常对动脉粥样硬化产生及斑块破裂的影响，提供一个尽量接近在体环境的、多种参数可调控的体外模拟平台。
Objective To design and develop the mural coronary artery circumferential stress in vitro simulation device, to achieve the loading of mural circumferential stress in vitro under different degrees coronary myocardial bridge oppression. Methods Using the myocardial bridge coronary artery hemodynamics in vitro simulation device to achieve the measurement experiment of the circumferential stress of the mural coronary artery, and based on the this experimental data to achieve the loading of mural circumferential stress in vitro under different degrees coronary myocardial bridge oppression. Results Through the measurement experiment of mural coronary artery circumferential stress found that the mural coronary artery in heart period of circumferential stress and the maximum average fluctuation will increase significantly with the increase of the degree of myocardial bridge oppression. The load experiment waveform coincided basically with the measurement experimental waveform. Conclusions The device can realize the circumferential stress loading of the mural coronary artery in vitro, which provided an in vitro simulation platform that is as close as possible to the in vivo environment to explore the influence of hemodynamic anomalies of the proximal mural coronary artery on the occurrence of atherosclerosis and plaque rupture.