初级纤毛在关节软骨中的生物力学效应
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作者单位:

1.天津中医药大学 针灸推拿学院;2.天津大学 精密仪器与光电子工程学院

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基金项目:

国家自然科学基金青年基金;国家级大学生创新创业训练项目;大学生科技创新基金项目


Biomechanical Effects of Primary Cilia in Articular Cartilage
Author:
Affiliation:

1.School of Acupuncture-Moxibustion and Tuina,Tianjin University of Traditional Chinese Medicine;2.School of Precision Instruments and Optoelectronics Engineering,Tianjin University

Fund Project:

National Natural Science Foundation of China、National College Students’ Innovative and Entrepreneurial Training Program、College students’ Scientific and Technological Innovation Foundation

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    摘要:

    生物力学因素对于关节软骨的稳态维持具有至关重要的作用。初级纤毛是一种可同时感受机械信号和化学信号的独立器官,近年来研究发现软骨细胞膜表面也有初级纤毛分布。其与多个信号转导通路相关,共同参与软骨细胞表型维持和物质代谢的过程。同时初级纤毛的异常也关联到多种人类的骨关节类疾病。本文主要论述了初级纤毛在软骨细胞力学微环境中的作用,以及与其他信号通路的交互作用机制,探讨了其与骨关节疾病的联系,以期为骨科临床和基础科研提供一定的科学依据。

    Abstract:

    Biomechanical factors play a crucial role in the steady state maintenance of articular cartilage. Primary cilium is an independent organ that can simultaneously sense mechanical and chemical signals. It has been found in recent years on the surface of chondrocyte membranes. It is involved in multiple signal transduction pathways and is involved in the process of chondrocyte phenotype maintenance and material metabolism. At the same time, abnormalities in primary cilia are also associated with a variety of human bone and joint diseases. This paper mainly discusses the mechanism of primary cilia in the mechanical microenvironment of chondrocytes, and the interaction with other signaling pathways, and explores its relationship with bone and joint diseases, in order to provide a scientific basis for orthopedic clinical and basic scientific research.

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历史
  • 收稿日期:2019-12-02
  • 最后修改日期:2020-02-21
  • 录用日期:2020-02-27
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