受载骨内液流刺激信号跨尺度传导行为研究
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太原理工大学生物医学工程学院

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国家自然科学基金(No.116320131, 11702183, 11402162,11572213)、山西自然科学基金(No.2016021145)、山西省高校科技创新项目(No.2017135)


Study on the trans-scale conduction behavior of fluid stimulation in loaded bone
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1.College of Biomedical Engineering,Taiyuan University of Technology,Taiyuan,Shanxi,030024;2.College of Biomedical Engineering,Taiyuan University of Technology

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    摘要:

    目的 骨骼具有复杂的层次结构,不同的层次具有不同的材料属性和功能。建立一个多尺度的多孔弹性有限元模型,探索生理载荷诱导的流体流动在骨内不同层次的不同生物功能单元中的液流刺激信号的传导行为。方法 利用COMSOL Multiphysics软件建立多尺度三维有限元模型,从宏观-细观-微观不同尺度分析孔隙压力和流速在不同层次上的变化规律。结果 在宏细观尺度上,靠近骨外膜和骨内膜处的骨单元内的压力和流速分布与其他部位的骨单元有明显不同;在细微观尺度上分析了沿着骨组织半径方向和沿着骨单元半径方向骨陷窝和骨小管的孔隙压力,液体流速和流体切应力的变化规律。由于不同层次的结构和材料参数的差别较大,载荷和流体压力由宏观传递到微观的过程中会引起不同的生物力学响应。结论 本文对一段截取的骨组织进行了骨结构-骨单元-骨陷窝-骨小管的多尺度分层建模,为更深层次的理解骨内液流信号传递和力传导提供一个理论参考。

    Abstract:

    Objective Bones have composite hierarchical structures, and different hierarchical levels exhibit diverse material properties and functions. To construct a multiscale model of the cortical bone that includes different biological functional units, investigate the conduction behavior of fluid flow induced by physiological loads at different scales of bone. Methods The COMSOL Multiphysics software was used to establish multiscale bone models, and the fluid behaviors were investigated through macro-, meso-and micro-scale. Results The maximum values of the pore pressure and fluid velocity was observed in the position of periosteum at macro-meso scale,and the minimum values was observed in the position of endosteum. The changes of pore pressure, fluid velocity and fluid shear stress of lacunae and canaliculi along the radius of bone tissue and osteon were analyzed at meso-micro scale. Due to the different structure and material parameters in different layers, the loading and fluid pressure caused different biomechanical responses in the process of transferring from macroscale to microscale. Conclusions A multi-scale bone model including whole bone structure,osteon,lacuna and canaliculi was established for a section of bone tissue, which provided a theoretical reference for a deeper understanding of fluid stimulation and mechanotransduction.

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  • 收稿日期:2019-07-11
  • 最后修改日期:2019-09-13
  • 录用日期:2019-11-12
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