Objective：To explore the dynamics of the free state of the osteoporotic vertebral body in the thoracolumbar region.Methods: To choose a healthy female volunteer,the CT data of the Dicom format of the thoracic and lumbar vertebral body of the volunteers were extracted, and the computerized processing software (Mimics 14.0、UG NX 8.5,etc.) was used to realize model materialization and intervertebral disc tissue reconstruction,the above model was introduced into Abaqus 6.14 software to establish a finite element model of normal thoracolumbar vertebral body and thoracolumbar osteoporotic vertebral body, and modal analysis was performed.Results:The natural frequency of the osteoporosis group model is lower than that of the normal group model, and the amplitude increases. As the vibration frequency increases, the model vibration type changes from uniaxial and unidirectional motion to multiaxial and multidirectional motion, and the maximum amplitude responsible vertebral body move down gradually.Conclusion: The modal analysis can better analyze the dynamic characteristics of the thoracolumbar osteoporotic vertebral body. Patients with osteoporosis should try to avoid the specific vibration environment and avoid the increase of intervertebral disc tissue degeneration, thoracolumbar Risk of soft tissue strain and posterior structural changes in the vertebral body.