血管细胞在体力学微环境的简析
DOI:
作者:
作者单位:

上海交通大学 船舶海洋与建筑工程学院

作者简介:

通讯作者:

中图分类号:

基金项目:

国家重点计划政府间国际合作项目 2017YFE0117100; 国家自然科学基金 11872040,11232010


In vivo mechanical niches of vascular cells
Author:
Affiliation:

Key Laboratory of Hydrodynamics Ministry of Education,Department of Engineering Mechanics,School of Naval Architecture,Ocean and Civil Engineering,Shanghai Jiao Tong University

Fund Project:

National Key R&D Program of China (2017YFE0117100) and National Natural Science Foundation of China (11872040, 11232010)

  • 摘要
  • |
  • 图/表
  • |
  • 访问统计
  • |
  • 参考文献
  • |
  • 相似文献
  • |
  • 引证文献
  • |
  • 资源附件
  • |
  • 文章评论
    摘要:

    在脉搏血压和血流作用下血管承受的弹性应力、粘性剪切应力以及管壁基质的力学特性构成血管细胞的在体力学微环境,这些力学刺激参与调控管壁细胞的生物学响应,诱导血管组织的重建和病变。虽然目前有大量关于血管力学生物学的实验研究,但是体外实验中施加的力学刺激与血管生理和病理条件的定量相关性仍缺乏必要的讨论。本文总结了血管细胞在体力学微环境的量化评估方法,聚焦生理位置和老化对管壁力学行为的影响。本文探讨了细胞力学微环境的生理和病理特性,以及对当前血管力学生物学研究的启示。

    Abstract:

    The elastic stress and viscous shear stress experienced by the vessel wall under pulse blood pressure and blood flow and the mechanical properties of the substrate constitute the in vivo mechanical niches of vascular cells, and these mechanical stimuli are involved in regulating the biological responses of vascular cells and inducing the remodeling and pathological changes of vascular tissues. Although many experimental studies on vascular mechanobiology have been reported, the quantitative correlation between the mechanical stimuli of in vitro experiments and the physiological and pathological conditions of blood vessels remains to be elucidated. This paper summarizes the quantitative evaluation methods of in vivo mechanical niches of vascular cells from the viewpoint of biomechanics, and then focuses on the effects of the physiological locations and aging on the mechanical behaviors of the vessel wall. This paper explores the physiological and pathological characteristics of the cellular mechanical niches and their implications for current vascular mechanobiological studies.

    参考文献
    相似文献
    引证文献
引用本文
分享
文章指标
  • 点击次数:
  • 下载次数:
  • HTML阅读次数:
  • 引用次数:
历史
  • 收稿日期:2019-04-30
  • 最后修改日期:2019-07-05
  • 录用日期:2019-08-05
  • 在线发布日期:
  • 出版日期: