定向拉伸工艺对可吸收肩袖补片力学性能的影响
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1.北京航空航天大学生物与医学工程学院 北京;2.北京市医用内植物工程技术研究中心;3.功能性医用材料与器械北京市工程实验室;4.北京航空航天大学生物与医学工程学院;5.生物医学工程高精尖创新中心 北京航空航天大学

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国家科技计划(国家重点研发计划),(项目编号:210YBXM2016110002)


Influence of unidirectional stretching processing on mechanical properties of bioresorbable patch for rotator cuff repair
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1.School of Biological Science and Medical Engineering, Beihang University;2.Beijing Medical Implant Engineering Research Center;3.Beijing Engineering Laboratory of Functional Medical Materials and Devices;4.Beijing Advanced Innovation Centre for Biomedical Engineering, Beihang University

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    摘要:

    目的 可吸收补片常用于增强肩袖撕裂,以降低肩袖损伤修复的失败率。目前,可吸收补片的力学性能不足是其主要问题。本文目的是研究定向拉伸工艺对不同可吸收补片力学性能的影响,评价其作为肩袖损伤修复补片的潜力。方法 采用定向拉伸工艺制备不同材料的可吸收补片,设定不同的定向拉伸温度和拉伸比,研究不同参数对不同材料可吸收补片力学性能的影响,同时对其热性能、结晶性能和表面形貌进行了表征。结果 不同的定向拉伸温度和拉伸比条件下,可吸收补片具有不同的拉伸强度和拉伸应变,其中,拉伸强度分别为74±7 MPa,97±6 MPa和107±8 MPa(>犬类冈下肌腱的力学强度~40MPa),但仅有聚左旋丙交酯-外消旋丙交酯的共聚物补片的应变满足天然肩袖的柔韧性。结论 定向拉伸工艺可以提高可吸收补片的力学性能,聚左旋丙交酯-外消旋丙交酯的共聚物补片具有补强肩袖撕裂的潜力。

    Abstract:

    Objective Absorbable patches are often used to enhance rotator cuff tears to reduce the failure rate of rotator cuff repair. At present, the lack of mechanical properties of absorbable patches is a major problem. The purpose of this study is to investigate the effect of directional stretching on the mechanical properties of different absorbable patches and evaluate its potential as a patch for rotator cuff repair. Methods The directional stretching process was used to prepare absorbable patches of different materials. The different directional stretching temperatures and draw ratios were set. The effects of different parameters on the mechanical properties of the absorbable patches for different materials were studied. Their thermal properties, crystallization and surface morphology were characterized. Results Under different directional stretching temperatures and draw ratios, the absorbable patches have different tensile strength and tensile strain. The tensile strength are 74±7 MPa, 97±6 MPa and 107±8 MPa (>~40MPa for tensile strength of infraspinatus tendon of canine), respectively. However, only the strain of the patch made of poly-L-lactide-co-ε-caprolactone conformed to the flexibility of natural rotator cuff. Conclusions The directional stretching process can improve the mechanical properties of the absorbable patch. The absorbable patch made of poly-L-lactide-co-ε-caprolactone has the potential to reinforce the rotator cuff tear.

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  • 收稿日期:2019-03-19
  • 最后修改日期:2019-04-29
  • 录用日期:2019-04-30
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