肺内液粘度和表面张力测量的方法与临床意义
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1.上海理工大学;2.上海健康医学院;3.复旦大学附属中山医院

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国家自然科学基金面上项目(81770075);上海市教育委员会科研创新项目(15ZZ111)


Methods and clinical significance of measurement of fluid viscosity and surface tension in the lung
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1.University of Shanghai for Science and Technology;2.Shanghai University of Medicine&3.Health Sciences;4.ZhongShan Hospital affiliated to Fudan University

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    摘要:

    肺内液主要指由气道粘液和肺泡内表面衬里液所形成的一连续液体薄层,其对于维持肺的健康至关重要。本文介绍了肺内液流变学特性在维持气道稳定性、保证肺正常的屏障与清除功能、避免呼吸机相关性肺损伤和新生儿呼吸窘迫综合征表面活性剂替代治疗等方面的临床意义,同时总结了Langmuir-Wilhelmy天平法、捕获气泡法、毛细管粘度计和旋转粘度计等液体表面张力和粘度测量的经典方法以及粒子追踪微流变仪、轴对称液滴边缘形状分析等新技术,比较了这些方法的优缺点,为临床研究肺内液流变学特性辅助肺疾病的诊断和治疗提供了重要的参考。

    Abstract:

    Pulmonary fluid refers to a thin and continuous liquid layer mainly consisting of airway mucus and lining liquid on the inner surface of alveoli, which is essential for maintaining a healthy lung. This paper introduced the clinical significance of rheological properties of pulmonary fluid in airway stability, pulmonary barrier and clearance functions, ventilator induced lung injury and surfactant replacement therapy in infant respiratory distress syndrome. Furthermore, a variety of classical methods for measuring surface tension and liquid viscosity, such as Langmuir-Wilhelmy balance, captive bubble method, glass capillary viscometer and rotational viscometer, and emerging techniques (e.g. particle tracking microrheometer and axisymmetric drop shape analysis) were reviewed. A comparison of their advantages and drawbacks makes an important reference for the assisted diagnosis and treatment of lung diseases in clinical practice.

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历史
  • 收稿日期:2019-03-18
  • 最后修改日期:2019-04-22
  • 录用日期:2019-05-30
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