力学调控长链非编码RNA在间充质干细胞成骨分化的作用研究进展
DOI:
作者:
作者单位:

1.天津医科大学总医院 ,军事科学院卫勤保障技术研究所;2.军事科学院卫勤保障技术研究所,天津理工大学;3.军事科学院卫勤保障技术研究所;4.天津医科大学总医院;5.天津市口腔医院,军事科学院卫勤保障技术研究所

作者简介:

通讯作者:

中图分类号:

基金项目:

国家自然科学基金资助项目(31470935、11432016)


Research advances in the effect of mechanical regulation of long-chain non-coding RNAs on osteogenic differentiation of mesenchymal stem cells
Author:
Affiliation:

1.Tianjin Medical University General Hospital,Institute of Medical Service and Technology ,Academy of Military Science;2.Institute of Medical Service and Technology ,Academy of Military Science,Tianjin University of Technology;3.Institute of Medical Service and Technology ,Academy of Military Science;4.Tianjin Medical University General Hospital;5.Tianjin Stomatological Hospital

Fund Project:

  • 摘要
  • |
  • 图/表
  • |
  • 访问统计
  • |
  • 参考文献
  • |
  • 相似文献
  • |
  • 引证文献
  • |
  • 资源附件
  • |
  • 文章评论
    摘要:

    随着第三代高通量测序技术和组织工程的发展,近些年来,发现许多长链非编码RNA(LncRNAs)在力学调节间充质干细胞的成骨分化中起重要作用。力学因素调控相关的LncRNAs,然后LncRNAs通过在转录、转录后以及表观遗传等多层次发挥调节作用,进一步调控骨相关细胞功能。LncRNAs也可能作为力学响应分子参与间充质干细胞B(MSCs)成骨分化、以及骨重建以及调控骨相关细胞功能,参与骨骼系统疾病的病理过程。

    Abstract:

    With the development of third-generation high-throughput sequencing technology and tissue engineering, many long-chain non-coding RNAs (LncRNAs) have been found to play an important role in the osteogenic differentiation of mesenchymal stem cells. LncRNAs, which are involved in the regulation of mechanical regulation, further regulate bone-related cell functions and play a regulatory role at multiple levels, including transcription, post-transcriptional and epigenetic. LncRNAs may be involved in the osteogenic differentiation and bone remodeling of MSCs and the regulation of bone-related cell functions as a mechanical response molecule, and participate in the pathological process of skeletal diseases.

    参考文献
    相似文献
    引证文献
引用本文
分享
文章指标
  • 点击次数:
  • 下载次数:
  • HTML阅读次数:
  • 引用次数:
历史
  • 收稿日期:2019-02-26
  • 最后修改日期:2019-04-04
  • 录用日期:2019-04-10
  • 在线发布日期:
  • 出版日期: