新型可降解锌合金支架的结构设计 及其力学性能分析
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北京工业大学

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国家自然科学基金资助项目(11772015),北京市教委科技计划重点项目暨北京市自然科学基金B类项目(KZ201710005007)


Structure Design and Mechanical Analysis of Biodegradable Zinc Alloy Stent
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Beijing University of Technology

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    摘要:

    摘要: 目的 本研究旨在对比分析一款新结构可降解支架和传统结构可降解支架力学性能和对狭窄血管的治疗效果。方法 利用有限元数值模拟,将新结构支架和传统结构支架分别植入直径狭窄为30%的血管,对比分析两种支架的支撑性能及其对狭窄血管重构的影响。结果 与传统结构支架相比,新结构支架的径向回弹率和狗骨头率分别降低了26.6 %和34.7%。此外,植入新结构支架的狭窄血管回弹较小,拥有更平滑更大的管腔。结论 对比传统结构支架,新结构支架具有更高的支撑性能,对狭窄血管的治疗效果更佳。具有高支撑刚度的新结构支架有望成为临床介入治疗设备的新选择。通过创新的结构设计,提高可降解支架的力学性能,对于推动可降解支架的临床应用具有重要意义。

    Abstract:

    Abstract--Objective This study aims to compare and analyze the scaffold performance of a new stent and a common stent which is chosen as a control group. Method Using finite element analysis, the new stent and the common stent are simulated to implant into vessels with a diameter stenosis of 30%, their scaffold performance and their effects on reshaping the stenotic vessels are investigated. Results Radial recoiling ratio and dog-boning ratio of the new stent are decreased by 26.6 % and 34.7% respectively compared with the common stent. Besides, a flatter and larger lumen can be observed in the plaque treated with the new stent. Conclusions The new stent has a stronger scaffold performance and a more brilliant effect on reshaping stenotic vessel, compared with the common stent. It is suggested that the new stent with strong scaffold performance is highly promised to be an alternative choice in interventional surgeries. Improving mechanical performance of biodegradable stents via novel structure design is of highly significance to promote clinical application of biodegradable stents.

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历史
  • 收稿日期:2018-12-17
  • 最后修改日期:2019-02-02
  • 录用日期:2019-02-18
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