整合素传递力学信号影响间充质干细胞分化的研究进展
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1.吉林大学白求恩医学部;2.吉林大学;3.吉林大学基础医学院

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国家自然科学基金(81572139),吉林省科技厅优秀青年人才基金项目(20190103094JH)资助


Research progress on the effect of integrins on Mesenchymal stem cells differentiation
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1.Jilin university Bethune medical department;2.Jilin University;3.Basic medical college of jilin university

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    摘要:

    本文简述了硬度的可控性及其控制方法、不同硬度调控间充质干细胞(mesenchymal stem cells,MSCs)分化的相应方向和整合素在硬度调控MSCs分化的信号通路中的作用。其中,重点说明了整合素在硬度调控MSCs分化的信号通路中的作用。硬度调控MSCs分化的信号通路包括Rho/ROCK信号通路、整合素/FAK信号通路、ERK信号通路、 JNK信号通路、 Wnt-β-catenin信号通路和PI3K/Akt信号通路等。而整合素作为跨膜异二聚体糖蛋白,参与部分信号通路传递力学信号给MSCs。不同的整合素家族参与不同的信号通路来调控MSCs向不同方向分化,且这些信号通路间存在或多或少的相互影响。此文旨在为组织修复、器官再造和再生医学等方面的应用提供理论依据。

    Abstract:

    The purpose of this review is to provide a theoretical basis for the application of tissue repair, organ regeneration and regenerative medicine.By reading a lot of documents,this paper simply described the contollability of ECM stiffness and its control methods, the direction of ECM with different rigidity in regulating MSC differentiation and the role of integrin in the signal pathway of ECM rigidity in regulating MSC differentiation . The role of integrin in the signaling pathway of ECM rigidity regulating MSC differentiation was highlighted. Signal pathways in which ECM stiffness regulates MSC differentiation include Rho/ROCK signal pathway, integrin /FAK signal pathway, ERK signal pathway, JNK signal pathway, wnt--catenin signal pathway and PI3K/Akt signal pathway, etc. Integrin, as a transmembrane heterodimer glycoprotein, participates in part of the signal pathway to transmit mechanical signals to MSC. Different integrin families participate in different signaling pathways to regulate MSC differentiation in different directions, and there are more or less mutual influences among these signaling pathways.

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历史
  • 收稿日期:2018-11-11
  • 最后修改日期:2019-01-21
  • 录用日期:2019-01-28
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