基于nmsBuilder和OpenSim建立个性化骨肌模型及其验证
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1.太原理工大学;2.太原理工大学生物医学工程学院

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国家自然科学(11472185,11772214)。通讯作者;陈维毅,教授,博士研究生导师,E-mail: chenweiyi211@163.com;王长江,教授,博士研究生导师,E-mail:727649260@qq.com


The building and verification for personalized musculoskeletal model based on softwares OpenSim and nmsBuilder
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School of Biomedical engineering,Taiyuan University Of Technology

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    摘要:

    目的 利用nmsBuilder和OpenSim两款免费软件构建个性化全膝关节置换假体后的骨骼肌肉多体动力学模型并用弹跳式和内推式两种步态对构建模型进行验证分析。 方法 利用患者的骨骼数据,通过nmsBuilder建立实体、骨标点和肌肉标点,从而自动生成对应参考系统和肌肉,将nmsBuilder生成的骨肌模型导入OpenSim先后执行逆向运动学、静态优化和膝关节接触力分析,最后通过弹跳式和内推式两种步态对模型进行模拟分析并与实验测量值进行对比验证。结果 除了外侧关节接触力,模型预测的胫股关节接触力幅值和趋势与实验获得数据对比有很好的一致性,构建的骨骼肌肉多体动力学模型可以被用于膝关节方面的研究。结论 本文利用患者的骨骼信息建立的骨肌模型通过输入标记点位置和地面反作用力,可以同时预测出内侧、外侧以及总胫股关节接触力。本文的研究思路还可以被用来为患者设计个性化膝关节假体。通过搜集患者的术前步态数据和骨骼信息进行 “虚拟手术”,从而为患者寻找最适合的假体,或者设计出适合该患者的个性化假体。

    Abstract:

    Obiective To build a personalized musculoskeletal multi-body dynamics model of total knee replacement by two free software nmsbuilder and opensim, and verify the model use bouncy and medthrust two gait pattners by comparing results of experiment and model. Methods Based on MRI and STL skeletal data from patient, bodys, skeletal landmark clouds and muscular landmark clouds were established for reference systems and muscles automatically. Results In addition to the lateral joint contact forces, the magnitude and trend of the knee joint contact forces which the model predicted have a good agreement with the experimental data,the constructed skeletal muscle multi-body dynamics model can be used for knee joint research. Conclusions The established musculoskeletal multi-body dynamics model predicts the medial, lateral, and total tibiofemoral joint contact forces simultaneously by inputting the position of markers and the ground reaction forces. The ideas of this study can be used to design personalized knee prostheses. A "virtual surgery" is performed after collecting the patient's preoperative gait data and skeletal data to find the most suitable prosthesis for the patient, or further, to design a personalized prosthesis suitable for the patient.

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  • 收稿日期:2018-09-23
  • 最后修改日期:2019-01-15
  • 录用日期:2019-01-28
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