实体肿瘤内微循环及药物传递的三维数值模拟
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国家自然科学基金资助项目(10772051)


Three dimensional numerical simulation of microcirculation and drug delivery in solid tumors
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    摘要:

    目的 研究实体肿瘤内微环境流动特征及大分子药物在肿瘤组织内的输运过程。方法建立模拟肿瘤血液动力学及药物输运的三维模型。模拟肿瘤内的微循环以及两种大分子药物在肿瘤内的浓度分布。结果模拟结果很好地反映了肿瘤内异常的血液动力学特性,以及由此造成的药物输运屏障、浓度分布不均匀性等特征。研究还表明,分子量较小的药物更易在肿瘤组织内传递,也更易随着组织液流动向肿瘤外排出;分子量较大的药物较易在肿瘤内部积聚,从而能在较长时间内保持一定的有效药物浓度。结论本模型计算结果与生理实际相符,为研究肿瘤微环境,药物输运,以及制定药物治疗策略提供了可信的模型及数值研究手段。

    Abstract:

    Objective To study the characteristics of microenvironmental flow and the process of macromolecular drug delivery in solid tumor. Method3D models simulating tumor hemodynamics and drug delivery were developed. Microcirculation and concentration distribution of two macromolecular drugs in tumor were simulated. ResultsThe model successfully reflected abnormal tumor hemodynamics, which results in impeded drug delivery and uneven concentration distribution of the drug. The results also shows that the drug with lower molecular weight is more easy to spread in tumor and excrete with interstitial fluid flow. In contrast, the drug with higher molecular weight tends to accumulate and maintain an effective concentration in tumor for a longer period. ConclusionsThe results derive from this model can reflect physiological conditions, providing a reliable numerical model for the investigation of tumor microenvironment, drug delivery and strategy of therapy.

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吴洁,许世雄,龙泉,丁祖荣.实体肿瘤内微循环及药物传递的三维数值模拟[J].医用生物力学,2010,25(2):129-135

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  • 收稿日期:2010-01-20
  • 最后修改日期:2010-02-06
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