目的 改善钛合金植入体的长期生物相容性和机械稳定性。方法 通过溶胶凝胶工艺和浸渍提拉技术，以钛酸丁酯(TEOT)为前躯体，加入聚乙二醇(PEG)作为模板剂，在钛合金基片上制备了TiO2微纳图案化薄膜，通过AFM研究了PEG的加入量对薄膜表面微观形貌的影响，并利用光学接触角测量仪与UMT-2型摩擦磨损试验机对薄膜的浸润性及摩擦学性能进行了研究。结果 当PEG浓度增至3.5g/100mL时，样品表面呈现出较为规则的平行排列的沟槽状结构；具有图案化结构的TiO2薄膜的耐磨性能较未加入模板剂的TiO2溶胶凝胶薄膜有明显提高。结论 可以通过控制模板剂的用量来实现对TiO2薄膜图案化特征的渐变控制，并证明了特定的图案化微观结构可以提高薄膜的抗磨损性能。

Objective To improve the long-term biocompatibility and mechanical stability of Titanium alloy implants. Method micro-nano patterned TiO2 thin films have been prepared on TC4 substrates via a sol-gel dip-coating method with Ti(OC4H9)4 (TEOT) as precursor and polyethylene glycol (PEG) as organic template. The influence of PEG concentration upon the morphology of the target films has been studied by using AFM. The wettability and tribological properties of the target films have been studied by means of optical contact angle measuring instrument and UMT-2. Results When increasing the PEG concentration to 3.5g/100mL, a parallel arranged groove structure can be obtained on the surface of the sample; compare with TiO2 sol-gel film without adding organic template, the wear resistance of the patterned film is better. Conclusions The feature of the patterned TiO2 films can be controlled by adding different amount of organic template; and it has been proved that a certain kind of patterned structure can improve the wear resistance of the film.

国家自然科学基金资助项目（30300078)；上海交通大学医工（理)交叉基金资助项目（YG2007MS17)；教育部留学归国人员科研启动基金